Université Paris-Saclay, CIAMS, 91405, Orsay, France.
Université d'Orléans, CIAMS, 45067, Orléans, France.
Philos Trans R Soc Lond B Biol Sci. 2020 May 25;375(1799):20190232. doi: 10.1098/rstb.2019.0232. Epub 2020 Apr 6.
Sleep spindle activity has repeatedly been found to contribute to brain plasticity and consolidation of both declarative and procedural memories. Here we propose a framework for motor memory consolidation that outlines the essential contribution of the hierarchical and multi-scale periodicity of spindle activity, as well as of the synchronization and interaction of brain oscillations during this sleep-dependent process. We posit that the clustering of sleep spindles in 'trains', together with the temporally organized alternation between spindles and associated refractory periods, is critical for efficient reprocessing and consolidation of motor memories. We further argue that the long-term retention of procedural memories relies on the synchronized (functional connectivity) local reprocessing of new information across segregated, but inter-connected brain regions that are involved in the initial learning process. Finally, we propose that oscillatory synchrony in the spindle frequency band may reflect the cross-structural reactivation, reorganization and consolidation of motor, and potentially declarative, memory traces within broader subcortical-cortical networks during sleep. This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.
睡眠纺锤波活动被反复发现有助于大脑的可塑性和陈述性及程序性记忆的巩固。在这里，我们提出了一个运动记忆巩固的框架，概述了睡眠依赖过程中纺锤波活动的分层和多尺度周期性、以及脑振荡的同步和相互作用的基本贡献。我们假设睡眠纺锤波在“波列”中的聚类，以及纺锤波和相关不应期之间的时间组织交替，对于运动记忆的有效再处理和巩固至关重要。我们进一步认为，程序性记忆的长期保留依赖于新信息在参与初始学习过程的分离但相互连接的脑区之间的同步（功能连接）局部再处理。最后，我们提出，纺锤波频段的振荡同步可能反映了运动和潜在的陈述性记忆痕迹在睡眠期间在更广泛的皮质下-皮质网络中的跨结构重新激活、重组和巩固。本文是“记忆再激活：回放过去、现在和未来的事件”主题会议的一部分。
