Department of Oral Biology, Faculty of Dentistry, Thammasat University (Rangsit Campus), Pathum Thani, Thailand.
Department of Pediatric Dentistry, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia.
J Asthma. 2021 Aug;58(8):1051-1057. doi: 10.1080/02770903.2020.1753211. Epub 2020 Apr 23.
OBJECTIVE: The aim of this study was to investigate the caries risk of asthmatics in relation to acidogenicity and the expression of caries-related genes in dental plaque. METHODS: A case-control study composed of 38 asthmatics (cases) and 22 controls with an age range from 6 to 60 years. Characteristics of asthma, use of medications, oral hygiene practices and dietary habits assessed by questionnaires and interviews. The dental plaque maturity evaluated using GC Tri Plaque ID Gel TM. The expression of , , , , and genes analyzed using real-time PCR. RESULTS: Asthmatics had a higher percentage of mature and acidogenic plaque than immature plaque. In contrast, immature plaque was more evident in controls. Acidogenic plaque commonly occurred in patients using 1 or a combination of two medications. High frequency in meals and sweets were found in asthmatics. Real-time PCR revealed that the expression of , , , , and were enhanced in asthmatics compared with the control group. CONCLUSION: An increase in acidogenic and mature plaque is found in asthmatics. The expression of , , , , and in dental plaque are upregulated in asthmatics.
目的：本研究旨在调查哮喘患者的龋齿风险与牙菌斑产酸能力和与龋齿相关基因的表达之间的关系。
方法：一项病例对照研究，共纳入 38 名哮喘患者（病例组）和 22 名年龄在 6 至 60 岁之间的对照者。通过问卷调查和访谈评估哮喘特征、药物使用、口腔卫生习惯和饮食习惯。使用 GC Tri Plaque ID Gel TM 评估牙菌斑成熟度。使用实时 PCR 分析 、 、 、 和 基因的表达。
结果：哮喘患者的成熟和产酸菌斑比例高于不成熟菌斑。相比之下，对照组中不成熟菌斑更为明显。使用 1 种或 2 种药物联合治疗的患者常出现产酸菌斑。哮喘患者经常进食和食用甜食。实时 PCR 显示，与对照组相比，哮喘患者中 、 、 、 和 基因的表达增强。
结论：哮喘患者的产酸和成熟菌斑增加。哮喘患者牙菌斑中 、 、 、 和 基因的表达上调。
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