Department of Medicine, Western University, Schulich School of Medicine & Dentistry, London, Ontario, Canada.
Department of Medicine, St. Joseph's Health Care London, Ontario, Canada.
Rheumatology (Oxford). 2020 Nov 1;59(11):3250-3258. doi: 10.1093/rheumatology/keaa095.
To estimate trends in the incidence and prevalence of GCA over time in Canada.
We performed a population-based study of Ontario health administrative data using validated case definitions for GCA. Among Ontario residents ≥50 years of age we estimated the annual incidence and prevalence rates between 2000 and 2018. We performed sensitivity analyses using alternative validated case definitions to provide comparative estimates.
Between 2000 and 2018 there was a relatively stable incidence over time with 25 new cases per 100 000 people >50 years of age. Age-standardized incidence rates were significantly higher among females than males [31 cases (95% CI: 29, 34) vs 15 cases (95% CI: 13, 18) per 100 000 in 2000]. Trends in age-standardized incidence rates were stable among females but increased among males over time. Incidence rates were highest among those ≥70 years of age. Standardized prevalence rates increased from 125 (95% CI 121, 129) to 235 (95% CI 231, 239) cases per 100 000 from 2000 to 2018. The age-standardized rates among males rose from 76 (95% CI 72, 81) cases in 2000 to 156 (95% CI 151, 161) cases per 100 000 population in 2018. Between 2000 and 2018, the age-standardized rates among females similarly increased over time, from 167 (95% CI 161, 173) to 304 (95% CI 297, 310) cases per 100 000 population.
The incidence and prevalence of GCA in Ontario is similar to that reported in the USA and northern Europe and considerably higher than that reported for southern Europe and non-European populations.
评估加拿大时间范围内巨细胞动脉炎（GCA）发病率和患病率的趋势。
我们对安大略省的健康管理数据进行了基于人群的研究，使用了经过验证的 GCA 病例定义。在≥50 岁的安大略省居民中，我们估计了 2000 年至 2018 年的年发病率和患病率。我们使用替代的经过验证的病例定义进行了敏感性分析，以提供比较估计。
在 2000 年至 2018 年期间，发病率相对稳定，每 10 万名≥50 岁人群中有 25 例新发病例。标准化发病率在女性中明显高于男性[2000 年为每 10 万人 31 例（95%CI：29，34），而男性为每 10 万人 15 例（95%CI：13，18）]。女性的标准化发病率趋势稳定，但随时间推移男性的发病率逐渐升高。发病率在≥70 岁的人群中最高。标准化患病率从 2000 年的 125（95%CI 121，129）例增加到 2018 年的 235（95%CI 231，239）例/10 万人。2000 年男性的标准化发病率从每 10 万人 76 例（95%CI 72，81）上升到 2018 年的 156 例（95%CI 151，161）例/10 万人。在 2000 年至 2018 年期间，女性的标准化发病率也随时间推移而增加，从每 10 万人 167 例增加到 304 例（95%CI 297，310）例。
安大略省 GCA 的发病率和患病率与美国和北欧报道的相似，远高于南欧和非欧洲人群的报道。
