Pan M C, Zhou X W, Liu Y, Wang Y N, Qiu X G, Wu S F, Liu Q
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Chongxin Judicial Expertise Center, Wuhan 430403, China.
Fa Yi Xue Za Zhi. 2020 Feb;36(1):115-119. doi: 10.12116/j.issn.1004-5619.2020.01.022.
Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well. Poisoning cases caused by aconitum medicinal liquor are frequently encountered in the practice of forensic medicine. The molecular mechanisms of myocardial toxicity of these two drugs have much in common, and both of them affect the sodium channel, calcium channel and potassium channel of myocardial cell membrane and so on. This paper analyzes and discusses the possible co-effects of ethanol-aconitine on cardiomyocyte channel proteins, by reviewing researches on the mechanism of cardiotoxicity of ethanol and aconitine in recent years, in order to provide ideas and references for the research on the molecular mechanism of arrhythmia caused by combined poisoning.
乌头是应用最为广泛的中药材之一，而乌头碱是其主要毒性成分。乌头碱可诱发多种心律失常，导致死亡。急性饮酒也会引起心律失常。在法医学实践中，经常会遇到乌头药酒中毒的案例。这两种药物心肌毒性的分子机制有很多共同之处，它们均会影响心肌细胞膜的钠通道、钙通道和钾通道等。本文通过综述近年来乙醇和乌头碱心脏毒性机制的研究，分析和探讨乙醇 - 乌头碱对心肌细胞通道蛋白可能产生的共同作用，以期为联合中毒致心律失常的分子机制研究提供思路和参考。
