Gao Yabin, Fan Hang, Nie Anzheng, Yang Kang, Xing Haiyan, Gao Zhiqing, Yang Liujie, Wang Zheng, Zhang Linqi
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China.
Changzhou Hygiene Vocational Technology College, Changzhou, 213000, China.
J Ethnopharmacol. 2022 Jul 15;293:115270. doi: 10.1016/j.jep.2022.115270. Epub 2022 Apr 8.
Aconitine, a C-norditerpenoid alkaloid, derives from many medicinal plants such as Aconitum carmichaelii Debx. (Chinese:), Aconitum kusnezoffii Reichb (Chinese:), which were used to rheumatic fever, painful joints and some endocrinal disorders.
The present paper reviews research progress relating to the pharmacokinetics, physiological and pathological processes of aconitine, while some promising research direction and the detoxification of aconitine are also discussed.
The accessible literature on aconitine, from 1990 to 2020, obtained from published materials of electronic databases, such as SCI finder, PubMed, Web of Science, Science Direct, Springer and Google Scholar was systematically analyzed.
In this review, we address the pharmacokinetics of aconitine, as well as its pharmacological effects including anti-cancer, anti-inflammatory, anti-virus, immunoregulation, analgesic, insecticide and inhibition of androgen synthesis. Further, we summarize the toxicity of aconitine such as cardiotoxicity and neurotoxicity, on which we strikingly focus on the ways to reduce the toxicity of aconitine based.
Aconitine plays an vital role in a wide range of physiological and pathological processes and we can reduce the toxicity of aconitine by compatibility and hydrolysis. Although some issues still exist, such as the correlative relationship between the dose and toxicity of aconitine not being clear, our review may provide new ideas for the application of aconitine in the treatment of related diseases.
乌头碱是一种C-去甲二萜生物碱，来源于多种药用植物，如乌头（中药名：）、北乌头（中药名：），这些植物曾用于治疗风湿热、关节疼痛和一些内分泌失调疾病。
本文综述了乌头碱在药代动力学、生理和病理过程方面的研究进展，同时也讨论了一些有前景的研究方向以及乌头碱的解毒方法。
系统分析了1990年至2020年间从SCI finder、PubMed、Web of Science、Science Direct、Springer和Google Scholar等电子数据库发表的资料中获取的有关乌头碱的可获取文献。
在本综述中，我们阐述了乌头碱的药代动力学，以及其药理作用，包括抗癌、抗炎、抗病毒、免疫调节、镇痛、杀虫和抑制雄激素合成。此外，我们总结了乌头碱的毒性，如心脏毒性和神经毒性，在此基础上我们着重关注降低乌头碱毒性的方法。
乌头碱在广泛的生理和病理过程中发挥着重要作用，我们可以通过配伍和水解来降低乌头碱的毒性。尽管仍存在一些问题，如乌头碱剂量与毒性之间的相关关系尚不清楚，但我们的综述可能为乌头碱在相关疾病治疗中的应用提供新思路。
