Hasin D S, Grant B F, Endicott J
Columbia University, New York, New York.
Int J Addict. 1988 Aug;23(8):827-50. doi: 10.3109/10826088809058842.
We classified 123 alcohol rehabilitation patients by their histories of lifetime psychiatric comorbidity, and examined the demographic, social, occupational, treatment, and familial variables characterizing the groups. Diagnostic assessments were made with the SADS-L/RDC. High lifetime prevalences of major depressive disorder and drug use disorder were found. Aspects of treatment history distinguished between patient groups with and without lifetime major depression, but not other personal or familial variables. Patients with lifetime drug use disorders were younger and experienced an earlier onset of alcohol problems and treatment. Those with numerous childhood antisocial symptoms were younger, more likely to be male and unmarried, and less educated, and they had presented earlier for treatment. Subjects with two or more adult antisocial symptoms which occurred when subjects were not drinking or using drugs had a significant increase in family history of antisocial personality disorder. However, adult antisocial behaviors which were not separated from the effects of alcohol or drug use were unrelated to a family history of antisocial personality disorder. Implications of these findings are discussed.
我们根据123名酒精康复患者的终生精神疾病共病病史进行分类，并研究了表征这些群体的人口统计学、社会、职业、治疗和家庭变量。使用情感障碍和精神分裂症检查提纲（SADS-L/RDC）进行诊断评估。发现重度抑郁症和药物使用障碍的终生患病率很高。治疗史方面区分了有和没有终生重度抑郁症的患者组，但其他个人或家庭变量则没有。有终生药物使用障碍的患者更年轻，酒精问题和治疗的发病更早。有大量童年反社会症状的患者更年轻，更可能是男性且未婚，受教育程度较低，并且更早接受治疗。当受试者不饮酒或不使用药物时出现两种或更多成人反社会症状的受试者，其反社会人格障碍家族史显著增加。然而，与酒精或药物使用影响未分开的成人反社会行为与反社会人格障碍家族史无关。讨论了这些发现的意义。
