Graduated Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 11041, Taiwan.
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan.
Drug Discov Today. 2020 May;25(5):828-836. doi: 10.1016/j.drudis.2020.03.017. Epub 2020 Apr 3.
Prodigiosin (PG), a red tripyrrole pigment, belongs to a member of the prodiginine family and is normally secreted by various sources including Serratia marcescens and other Gram-negative bacteria. The studies of PG have received innovative devotion as a result of reported antimicrobial, larvicidal and anti-nematoid immunomodulation and antitumor properties, owing to its antibiotic and cytotoxic activities. This review provides a comprehensive summary of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, the current evidence-based understanding of the biological activities and medicinal potential of PG is employed to determine the efficacy, with some reports of information related to pharmacokinetics, pharmacodynamics and toxicology.
灵菌红素（PG），一种红色三吡咯色素，属于灵菌红素家族的一员，通常由多种来源分泌，包括粘质沙雷氏菌和其他革兰氏阴性菌。由于其抗生素和细胞毒性活性，PG 的抗微生物、杀幼虫和抗线虫免疫调节和抗肿瘤特性的报道引起了人们对其进行创新性研究的关注。本文综述了对灵菌红素类天然产物的分离和结构阐明所进行的研究。此外，还利用目前基于证据的对 PG 的生物活性和药用潜力的理解来确定其疗效，其中一些报告涉及与药代动力学、药效学和毒理学相关的信息。
