Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Bioorg Chem. 2020 Jun;99:103760. doi: 10.1016/j.bioorg.2020.103760. Epub 2020 Mar 14.
Eight unexpected vibralactone homodimers, bisvibralactones A-H (1-8), and three new vibralactone monomers, hirsutumins A-C (9-11), were isolated from the culture of Stereum hirsutum. Their structures and absolute configurations were determined by detailed analyses of NMR, optical rotations, ECD, and high-resolution mass spectra as well as chemical transformation. Compounds 1-8 are unusual vibralactone dimers formed by the esterification of two vibralactone monomers. The absolute configurations of compounds 1 and 5 were determined by chemical conversions. All of the isolated compounds were evaluated for Porcine Pancreatic Lipase (PPL) inhibitory activities, and compound 10 showed significant inhibitory activity against PPL, with an IC value of 8.31 ± 1.04 μM.
从长毛栓菌（Stereum hirsutum）的培养物中分离得到了 8 个意想不到的 Vibralactone 同二聚体、BisVibralactones A-H（1-8）和 3 个新的 Vibralactone 单体，Hirsutumins A-C（9-11）。通过对 NMR、旋光、ECD 和高分辨率质谱以及化学转化的详细分析，确定了它们的结构和绝对构型。化合物 1-8 是由两个 Vibralactone 单体酯化形成的不寻常的 Vibralactone 二聚体。化合物 1 和 5 的绝对构型通过化学转化确定。所有分离得到的化合物均进行了猪胰脂肪酶（PPL）抑制活性评价，化合物 10 对 PPL 表现出显著的抑制活性，IC 值为 8.31±1.04 μM。
