Department of Bio-industrial Technologies, Konkuk University , Seoul 05029, Korea.
Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju, Chungbuk 28116, Korea.
J Nat Prod. 2016 Dec 23;79(12):3148-3151. doi: 10.1021/acs.jnatprod.6b00647. Epub 2016 Dec 8.
Ostalactones A-C (1-3), three new β- and ε-lactone natural products, were isolated from the culture broth of the basidiomycete Stereum ostrea. The structures were elucidated by interpretation of HRFABMS and 1D and 2D NMR data. The structures of 1 and 2 are characterized by the presence of a β-lactone containing a fused 4/5 bicyclic core structure. Compound 3 possesses a 2-oxepinone ring system, which is likely to be a biosynthetic precursor of compounds 1 and 2. Ostalactones A (1) and B (2) displayed potent inhibitory activity against human pancreatic lipase.
奥塔拉克托内 A-C（1-3），三种新的β-和ε-内酯天然产物，从担子菌 Stereum ostrea 的培养肉汤中分离得到。通过 HRFABMS 和 1D 和 2D NMR 数据分析阐明了结构。1 和 2 的结构特征是存在含有融合的 4/5 双环核心结构的β-内酯。化合物 3 具有 2-氧杂环庚酮环系统，可能是化合物 1 和 2 的生物合成前体。奥塔拉克托内 A（1）和 B（2）对人胰腺脂肪酶表现出强烈的抑制活性。
