Wood J B, Attwood E C, Wood B M, Dowling R M, Bradley F
Anaesthesia. 1977 Jan;32(1):21-4. doi: 10.1111/j.1365-2044.1977.tb11552.x.
A double-blind trial of the effects of vitamin C on the frequency, severity and duration of post-suxamethonium pains was performed. Fifty-three patients undergone bronchoscopy received either a placebo or 10 g of vitamin C. No beneficial effect was demonstrated. In 18 patients no relationship was found between pre-anaesthetic buffy layer vitamin C levels and the subsequent pains. Measurement of buffy layer and plasma vitamin C levels before and after anaesthesia did not suggest that vitamin C deficiency occurs during or immediately after administration of suxamethonium. It is concluded that the administration of vitamin C cannot be recommended as a means for prevention of suxamethonium pains.
进行了一项关于维生素C对琥珀胆碱后疼痛的频率、严重程度和持续时间影响的双盲试验。53例行支气管镜检查的患者接受了安慰剂或10克维生素C。未显示出有益效果。在18名患者中，未发现麻醉前血沉棕黄层维生素C水平与随后的疼痛之间存在关联。麻醉前后对血沉棕黄层和血浆维生素C水平的测量并未表明在琥珀胆碱给药期间或给药后立即出现维生素C缺乏。得出的结论是，不推荐使用维生素C来预防琥珀胆碱引起的疼痛。
