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贝达喹啉单独或与亚胺培南联合治疗 C3HeB/FeJ 小鼠脓肿分枝杆菌的疗效。

Efficacy of Bedaquiline, Alone or in Combination with Imipenem, against Mycobacterium abscessus in C3HeB/FeJ Mice.

机构信息

UVSQ, INSERM, Infection et Inflammation (U1173), Université Paris-Saclay, Montigny-le-Bretonneux, France

Institut de Recherche en Infectiologie de Montpellier, Centre National de la Recherche Scientifique UMR 9004, Université de Montpellier, Montpellier, France.

出版信息

Antimicrob Agents Chemother. 2020 May 21;64(6). doi: 10.1128/AAC.00114-20.

DOI:10.1128/AAC.00114-20
PMID:32253217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7269509/
Abstract

lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics, such as bedaquiline and imipenem, although data have questioned this combination. We report that the efficacy of bedaquiline-imipenem combination treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of The addition of imipenem contributed to clearing the infection in the spleen.

摘要

肺部感染仍然难以治疗。最近的研究已经认识到新的抗生素组合的力量，如贝达喹啉和亚胺培南，尽管数据对这种组合提出了质疑。我们报告说，贝达喹啉-亚胺培南联合治疗的疗效主要依赖于贝达喹啉在 C3HeB/FeJ 感染粗糙型变异株的小鼠模型中的活性。亚胺培南的加入有助于清除脾脏中的感染。

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本文引用的文献

1
Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.维拉帕米可提高贝达喹啉对脓肿分枝杆菌的体外和巨噬细胞内活性。
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.00705-19. Print 2019 Sep.
2
Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus.贝达喹啉消除β-内酰胺类药物对脓肿分枝杆菌的杀菌活性。
Antimicrob Agents Chemother. 2019 Jul 25;63(8). doi: 10.1128/AAC.00827-19. Print 2019 Aug.
3
Failure with acquired resistance of an optimised bedaquiline-based treatment regimen for pulmonary complex disease.基于贝达喹啉的优化治疗方案用于肺部复杂疾病时出现获得性耐药而导致治疗失败。
Eur Respir J. 2019 Jul 11;54(1). doi: 10.1183/13993003.00118-2019. Print 2019 Jul.
4
pulmonary disease: individual patient data meta-analysis.肺病：个体患者数据荟萃分析。
Eur Respir J. 2019 Jul 11;54(1). doi: 10.1183/13993003.01991-2018. Print 2019 Jul.
5
and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against .以及亚胺培南联合替加环素、利福布丁和阿维巴坦对 . 的细胞内活性。
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.01915-18. Print 2019 Apr.
6
A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria.贝达喹啉/氯法齐明联合方案可能为治疗有临床意义的非结核分枝杆菌增加活性。
J Antimicrob Chemother. 2019 Apr 1;74(4):935-943. doi: 10.1093/jac/dky526.
7
Activity of the New β-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with β-Lactams against Mycobacterium abscessus Complex Clinical Isolates.新型β-内酰胺酶抑制剂雷利巴坦和沃巴坦与β-内酰胺类药物联合对脓肿分枝杆菌复合体临床分离株的活性。
Antimicrob Agents Chemother. 2019 Feb 26;63(3). doi: 10.1128/AAC.02623-18. Print 2019 Mar.
8
and Intracellular Activity of Imipenem Combined with Rifabutin and Avibactam against Mycobacterium abscessus.并评估亚胺培南联合利福布汀和阿维巴坦对脓肿分枝杆菌的胞内活性。
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00623-18. Print 2018 Aug.
9
British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).英国胸科学会非结核分枝杆菌肺病（NTM-PD）管理指南。
Thorax. 2017 Nov;72(Suppl 2):ii1-ii64. doi: 10.1136/thoraxjnl-2017-210927.
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