Hamedani Ali G, Thibault Dylan P, Shea Judy A, Willis Allison W
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
Age Ageing. 2020 Aug 24;49(5):843-849. doi: 10.1093/ageing/afaa043.
Vision loss may be a risk factor for hallucinations, but this has not been studied at the population level.
To determine the association between self-reported vision loss and hallucinations in a large community-based sample of older adults, we performed a cross-sectional and longitudinal analysis of two large, nationally representative US health surveys: the National Health and Aging Trends Study (NHATS) and the Health and Retirement Study (HRS). Visual impairment and hallucinations were self- or proxy-reported. Multivariate single and mixed effects logistic regression models were built to examine whether visual impairment and history of cataract surgery were associated with hallucinations.
In NHATS (n = 1520), hallucinations were more prevalent in those who reported difficulty reading newspaper print (OR 1.77, 95% confidence interval (CI): 1.32-2.39) or recognising someone across the street (OR 2.48, 95% CI: 1.86-3.31) after adjusting for confounders. In HRS (n = 3682), a similar association was observed for overall (OR 1.32, 95% CI: 1.08-1.60), distance (OR 1.61, 95% CI: 1.32-1.96) and near eyesight difficulties (OR 1.52, 95% CI: 1.25-1.85). In neither sample was there a significant association between cataract surgery and hallucinations after adjusting for covariates.
Visual dysfunction is associated with increased odds of hallucinations in the older US adult population. This suggests that the prevention and treatment of vision loss may potentially reduce the prevalence of hallucinations in older adults.
视力丧失可能是幻觉的一个风险因素，但尚未在人群层面进行研究。
为了确定在一个基于社区的大型老年人群样本中自我报告的视力丧失与幻觉之间的关联，我们对两项具有全国代表性的美国大型健康调查进行了横断面和纵向分析：国家健康与老龄化趋势研究（NHATS）和健康与退休研究（HRS）。视力损害和幻觉由自我或代理人报告。构建多变量单因素和混合效应逻辑回归模型，以检验视力损害和白内障手术史是否与幻觉相关。
在NHATS（n = 1520）中，在调整混杂因素后，报告阅读报纸印刷品有困难（比值比[OR]1.77，95%置信区间[CI]：1.32 - 2.39）或识别街道对面的人有困难（OR 2.48，95% CI：1.86 - 3.31）的人群中幻觉更为普遍。在HRS（n = 3682）中，观察到总体视力困难（OR 1.32，95% CI：1.08 - 1.60）、远距离视力困难（OR 1.61，95% CI：1.32 - 1.96）和近距离视力困难（OR 1.52，95% CI：1.25 - 1.85）与幻觉之间存在类似关联。在两个样本中，调整协变量后白内障手术与幻觉之间均无显著关联。
视力功能障碍与美国老年人群中幻觉几率增加相关。这表明预防和治疗视力丧失可能会潜在地降低老年人幻觉的患病率。
