血小板与淋巴细胞比值及中性粒细胞与淋巴细胞比值在预测感染性糖尿病足溃疡患者住院时间和费用中的作用：一项回顾性比较研究。
The role of the platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in the prediction of length and cost of hospital stay in patients with infected diabetic foot ulcers: A retrospective comparative study.
作者信息
Eren Mehmet Ali, Güneş Ali Erdal, Kırhan İdris, Sabuncu Tevfik
机构信息
Department of Endocrinology, Harran University, School of Medicine, Şanlıurfa, Turkey.
Department of Undersea and Hyperbaric Medicine, Harran University, School of Medicine, Şanlıurfa, Turkey.
出版信息
Acta Orthop Traumatol Turc. 2020 Mar;54(2):127-131. doi: 10.5152/j.aott.2020.02.518.
OBJECTIVE
The aim of this study was to determine the role of new inflammatory markers, including the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), in the prediction of length and cost of hospital stay in patients with infected diabetic foot ulcers (DFUs).
METHODS
A total of 78 patients with DFUs who were admitted to our endocrinology clinic between January 2016 and July 2017 were included. Patients were then divided into three groups according to the Wagner DFU classification system: group 1: 18 patients with grade 2 DFU (11 men, 7 women; mean age = 57.5±7 years); group 2: 44 patients with grade 3 DFU (18 men, 26 women; mean age = 59.7±8.7 years); and group 3: 16 patients with grade 4 DFU (10 men, 6 women; mean age = 59.9±11.6 years). Laboratory findings were retrospectively obtained from hospital records; the PLR and NLR were calculated in all groups. Length and cost of hospital stay were recorded. Hospital costs were estimated in Turkish Lira (TL) based on the evaluation of glucose regulation, wound care, and antibiotic treatment.
RESULTS
The mean NLR was significantly lower in group 1 (2.8±0.9) than in group 2 (6.0±5.2; p=0.017) and group 3 (6.9±5.3; p=0.011). The mean PLR was significantly lower in group 1 (140.8±42.6) than in group 3 (222.1±95.5; p=0.006). The mean length of stay was 7.9±2.7 days in group 1, 15.0±8.9 days in group 2, and 12.5±8.9 days in group 3. The mean cost was 1,310.8±500 TL in group 1, 2,966.9±2105 TL in group 2, and 3,488.1±3603.1 TL in group 3. Length and cost of stay were both significantly lower in group 1 than in groups 2 and 3 (p=0.011 and p=0.002, respectively). Comparative results showed that the length and cost of hospital stay increased with increasing severity of DFUs. Furthermore, correlation analyses demonstrated no correlation of length of stay with PLR and NLR but an obvious correlation between cost of stay and PLR (r=0.412; p<0.001). Additionally, there was no correlation between cost of stay and NLR (r=0.158, p>0.05).
CONCLUSION
The PLR is inflammatory marker that can be measured by an inexpensive and easily accessible test and can aid in the prediction of length and cost of hospital stay in patients with DFUs.
LEVEL OF EVIDENCE
Level III, Therapeutic study.
目的
本研究旨在确定包括血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）在内的新型炎症标志物在预测感染性糖尿病足溃疡（DFU）患者住院时间和费用方面的作用。
方法
纳入2016年1月至2017年7月期间入住我院内分泌科的78例DFU患者。然后根据Wagner DFU分类系统将患者分为三组：第1组：18例2级DFU患者（11例男性，7例女性；平均年龄=57.5±7岁）；第2组：44例3级DFU患者（18例男性，26例女性；平均年龄=59.7±8.7岁）；第3组：16例4级DFU患者（10例男性，6例女性；平均年龄=59.9±11.6岁）。实验室检查结果通过回顾医院记录获得；计算所有组的PLR和NLR。记录住院时间和费用。根据血糖调节、伤口护理和抗生素治疗的评估，以土耳其里拉（TL）估算医院费用。
结果
第1组的平均NLR（2.8±0.9）显著低于第2组（6.0±5.2；p=0.017）和第3组（6.9±5.3；p=0.011）。第1组的平均PLR（140.8±42.6）显著低于第3组（222.1±95.5；p=0.006）。第1组的平均住院时间为7.9±2.7天，第2组为15.0±8.9天，第3组为12.5±8.9天。第1组的平均费用为1310.8±500 TL，第2组为2966.9±2105 TL，第3组为3488.1±3603.1 TL。第1组的住院时间和费用均显著低于第2组和第3组（分别为p=0.011和p=0.002）。比较结果显示，住院时间和费用随DFU严重程度的增加而增加。此外，相关性分析表明住院时间与PLR和NLR无相关性，但住院费用与PLR之间存在明显相关性（r=0.412；p<0.001）。此外，住院费用与NLR之间无相关性（r=0.158，p>0.05）。
结论
PLR是一种炎症标志物，可通过廉价且易于获得的检测方法进行测量，有助于预测DFU患者的住院时间和费用。
证据水平
三级，治疗性研究。
Zotero 插件