Paris Juan L, Villaverde Gonzalo, Cabañas M Victoria, Manzano Miguel, Vallet-Regí María
Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28040-Madrid, Spain.
J Mater Chem B. 2018 May 14;6(18):2785-2794. doi: 10.1039/c8tb00444g. Epub 2018 Apr 19.
In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategies necessary to afford a modular nanocarrier starting from a proof-of-concept material presented in previous work. This functional ultrasound-responsive material can be adapted to different specific pathological conditions by carefully choosing the appropriate targeting moieties. The new ultrasound responsive material is able to target HeLa cells when conjugated with biotin or an RGD peptide. Ultrasound-responsive cytotoxicity towards cancer cells of doxorubicin-loaded nanoparticles is demonstrated in an in vitro cytotoxicity assay.
在本研究中，我们展示了聚乙二醇化且具有主动靶向性的超声响应性杂化介孔二氧化硅纳米粒子的合成、表征及体外生物学评价。这项工作涵盖了从先前工作中提出的概念验证材料出发，开发出一种模块化纳米载体所需的化学策略。这种功能性超声响应材料可以通过仔细选择合适的靶向部分来适应不同的特定病理状况。当与生物素或RGD肽偶联时，这种新型超声响应材料能够靶向HeLa细胞。在体外细胞毒性试验中证实了载有多柔比星的纳米粒子对癌细胞具有超声响应性细胞毒性。
