Singh Rustam, Belgamwar Rajesh, Dhiman Mahak, Polshettiwar Vivek
Department of Chemical Sciences, Tata Institute of Fundamental Research (TIFR), Mumbai, India.
J Mater Chem B. 2018 Mar 21;6(11):1600-1604. doi: 10.1039/c8tb00310f. Epub 2018 Mar 5.
Mimicking enzymatic activity is a challenging task. Herein we report dendritic fibrous nano-silica (DFNS) supported gold (Au) nanoparticles (DFNS/Au) as a peroxidase like artificial enzyme. It showed a superior enzymatic activity in 3,5,3',5'-tetramethylbenzidine (TMB) oxidation chosen as a model reaction, significantly higher than natural horseradish peroxidase (HRP) enzyme as well as other reported nanomaterial based artificial enzymes. A solvent dependent selectivity towards a two-electron oxidation product, TMB-diamine, has also been observed. This study clearly indicates the vital role of the fibrous morphology and unique silica channels of DFNS in the enhancement of the enzymatic activity.
模拟酶活性是一项具有挑战性的任务。在此，我们报道了树枝状纤维纳米二氧化硅（DFNS）负载的金（Au）纳米颗粒（DFNS/Au）作为一种类过氧化物酶人工酶。在选为模型反应的3,5,3',5'-四甲基联苯胺（TMB）氧化反应中，它表现出卓越的酶活性，显著高于天然辣根过氧化物酶（HRP）以及其他已报道的基于纳米材料的人工酶。还观察到对双电子氧化产物TMB-二胺的溶剂依赖性选择性。这项研究清楚地表明了DFNS的纤维形态和独特二氧化硅通道在增强酶活性方面的重要作用。
