Liu Pei, Zheng Hongyi, Yang Zhe, Ba Li, Zhu Wei, Lin Leping, Xiong Yuxuan, Xu Zushun, Ren Jinghua
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei 430062, China.
J Mater Chem B. 2018 Mar 21;6(11):1688-1698. doi: 10.1039/c8tb00148k. Epub 2018 Mar 2.
Imaging-guided photodynamic/photothermal (PDT/PTT) synergetic therapy is important in more precise and efficient cancer treatment. Herein, gadolinium-chelated porphyrin-protein composite based on gold nanorods (GNRs@BPP-Gd) was synthesized through a straightforward and environmentally friendly method. Based on the high longitudinal relaxivity (9.544 mM s), GNRs@BPP-Gd can serve as a decent T-weighted magnetic resonance imaging (MRI) probe to steer treatment. A relevant cellular uptake assay showed that GNRs@BPP-Gd could be internalized into cancer cells effectively with negligible cytotoxicity. Furthermore, MRI-guided PDT/PTT studies in vivo indicated that GNRs@BPP-Gd could efficiently take effect after intravenous injection, leading to almost complete ablation at the tumor site. A single treatment was conducted for comparison with the combined treatment, indicating that synergetic therapy greatly enhanced the anti-tumor effect.
成像引导的光动力/光热（PDT/PTT）协同治疗在更精确、高效的癌症治疗中具有重要意义。在此，通过一种简单且环保的方法合成了基于金纳米棒（GNRs@BPP-Gd）的钆螯合卟啉-蛋白质复合物。基于高纵向弛豫率（9.544 mM s），GNRs@BPP-Gd可作为一种良好的T加权磁共振成像（MRI）探针来指导治疗。一项相关的细胞摄取试验表明，GNRs@BPP-Gd能够有效内化进入癌细胞，且细胞毒性可忽略不计。此外，体内MRI引导的PDT/PTT研究表明，GNRs@BPP-Gd静脉注射后可有效发挥作用，导致肿瘤部位几乎完全消融。进行了单次治疗与联合治疗的比较，结果表明协同治疗极大地增强了抗肿瘤效果。
