Li Wenxiang, Feng Ruyan, Wang Rensheng, Li Dan, Jiang Wenwen, Liu Hanzhou, Guo Zhenzhong, Serpe Michael J, Hu Liang
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China.
J Mater Chem B. 2018 Aug 7;6(29):4799-4807. doi: 10.1039/c8tb01160e. Epub 2018 Jul 9.
Physically crosslinked hydrogels were synthesized by copolymerization of acrylamide and acrylic acid monomers in the presence of cationic polyelectrolyte polydimethyldiallylammonium chloride. The fully physically crosslinked hydrogel showed good mechanical properties and good adhesion with a variety of substrates. These advantages can be attributed to the homogeneous distribution of crosslinking points due to hierarchical hydrogen bonds and electrostatic attractions in the hydrogel networks. Furthermore, these non-covalent bonds provided an effective pathway to dissipate energy. The mechanical properties of the hydrogels can be easily tuned by changing the chemical composition and ratio of monomers. We further showed that the transparent hydrogels were cytocompatible, and can be used for biomedical applications, including pH-triggered small molecule delivery and hydrogel-based hybrids for detecting doses of radiotherapy.
通过在阳离子聚电解质聚二甲基二烯丙基氯化铵存在下使丙烯酰胺和丙烯酸单体共聚合成了物理交联水凝胶。完全物理交联的水凝胶表现出良好的机械性能以及与多种底物的良好粘附性。这些优点可归因于水凝胶网络中由于分级氢键和静电吸引导致的交联点均匀分布。此外，这些非共价键提供了一种有效的能量耗散途径。通过改变单体的化学组成和比例可以轻松调节水凝胶的机械性能。我们进一步表明，透明水凝胶具有细胞相容性，可用于生物医学应用，包括pH触发的小分子递送以及用于检测放射治疗剂量的水凝胶基杂化物。
