Huang Lin, Liu Jia, Gao Fan, Cheng Qian, Lu Bo, Zheng Hua, Xu Haixing, Xu Peihu, Zhang Xianzheng, Zeng Xuan
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
J Mater Chem B. 2018 Jul 28;6(28):4618-4629. doi: 10.1039/c8tb00989a. Epub 2018 Jul 2.
In this study, a novel drug delivery system (HMSNs-SS-HA) based on hollow mesoporous silica nanoparticles (HMSNs) was developed for delivering anticancer drugs (e.g., doxorubicin (DOX)) to targeted tumour cells by using disulfide bonds as redox-sensitive linkers and hyaluronic acid (HA) molecules as both capping and targeting agents. Well-dispersed HMSNs were synthesized with a dimension of around 100 nm. Detailed physical characterization further demonstrated that HMSNs-SS-HA has been successfully constructed. The in vitro drug release experiments displayed the enzyme and redox dual-responsive and sustained drug release properties of DOX loaded HMSNs-SS-HA. Additionally, a series of biological evaluations indicated that these DOX loaded HMSNs-SS-HA could accurately target murine mammary carcinoma (4T1) cells to induce cell apoptosis in vitro and suppress tumour growth in vivo. These results demonstrated that DOX loaded HMSNs-SS-HA was suitable as a potential and efficient drug delivery nanosystem for cancer therapy.
在本研究中，基于中空介孔二氧化硅纳米粒子（HMSNs）开发了一种新型药物递送系统（HMSNs-SS-HA），通过使用二硫键作为氧化还原敏感连接子以及透明质酸（HA）分子作为封端和靶向剂，将抗癌药物（如阿霉素（DOX））递送至靶向肿瘤细胞。合成了尺寸约为100nm且分散良好的HMSNs。详细的物理表征进一步证明已成功构建了HMSNs-SS-HA。体外药物释放实验显示了负载DOX的HMSNs-SS-HA具有酶和氧化还原双重响应以及持续药物释放特性。此外，一系列生物学评估表明，这些负载DOX的HMSNs-SS-HA能够在体外准确靶向小鼠乳腺癌（4T1）细胞以诱导细胞凋亡，并在体内抑制肿瘤生长。这些结果表明，负载DOX的HMSNs-SS-HA适合作为一种潜在且高效的癌症治疗药物递送纳米系统。
