Dai Liangliang, Zhang Qingfeng, Shen Xinkun, Sun Qiang, Mu Caiyun, Gu Hao, Cai Kaiyong
Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China.
J Mater Chem B. 2016 Jul 14;4(26):4594-4604. doi: 10.1039/c6tb01050d. Epub 2016 Jun 16.
A pH-responsive drug delivery system based on hollow mesoporous silica nanoparticles (HMSNs) was fabricated for targeted tumor therapy by using hydrazone bonds as pH-sensitive linkers and hyaluronic acid (HA) molecules as both blocking and targeting agents. HMSNs were synthesized with good dispersion and dimensions of around 88 nm. Detailed material characterisation suggested that the drug delivery system was successfully constructed. It displayed a fast pH stimulus response for controlled drug release in vitro. Besides, systematic biological investigations revealed that the drug delivery system had good biocompatibility, which could effectively target tumor cells and deliver therapeutic cargo to induce tumor cell apoptosis in vitro and suppression of tumor growth in vivo. This study reports a promising drug delivery system for potential clinical application against tumor therapy.
基于中空介孔二氧化硅纳米粒子（HMSNs）构建了一种pH响应型药物递送系统，用于靶向肿瘤治疗，该系统以腙键作为pH敏感连接子，透明质酸（HA）分子既作为封闭剂又作为靶向剂。合成的HMSNs具有良好的分散性，尺寸约为88nm。详细的材料表征表明该药物递送系统已成功构建。它在体外对pH刺激显示出快速响应，可实现药物的可控释放。此外，系统的生物学研究表明该药物递送系统具有良好的生物相容性，能够有效靶向肿瘤细胞，并在体外递送治疗性药物以诱导肿瘤细胞凋亡，在体内抑制肿瘤生长。本研究报道了一种有前景的药物递送系统，有望用于肿瘤治疗的潜在临床应用。
