Luo Honglin, Xie Jing, Xiong Lingling, Yang Zhiwei, Zuo Guifu, Wang Hongying, Zhu Yong, Wan Yizao
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China.
J Mater Chem B. 2018 Jun 7;6(21):3515-3521. doi: 10.1039/c8tb00658j. Epub 2018 May 17.
The design and synthesis of multifunctional hydroxyapatite (HAp) nanoparticles are important in expanding their clinical applications. Herein we report a novel selenium (Se) and gadolinium (Gd) dual-doped lamellar hydroxyapatite (L-HAp-Se-Gd) produced by facile one-step template-assisted synthesis. The results show that the as-prepared L-HAp-Se-Gd nanoparticles exhibit obvious changes in morphology, dimensions, and crystallinity as compared to bare L-HAp. XRD results reveal that high dopant levels of Se and Gd reduce the degree of ordering of HAp lamellae. It is found that the L-HAp-Se-Gd nanoparticles display Gd content-dependent blue fluorescence under ultraviolet (UV) irradiation and magnetic properties. Cell tests with mouse embryo osteoblast cells (MC3T3-E1) reveal their improved biocompatibility over bare L-HAp due to Se incorporation. These results indicate that L-HAp-Se-Gd nanoparticles have potential in numerous applications such as multifunctional gene delivery and bioimaging.
多功能羟基磷灰石（HAp）纳米粒子的设计与合成对于拓展其临床应用具有重要意义。在此，我们报道了一种通过简便的一步模板辅助合成法制备的新型硒（Se）和钆（Gd）双掺杂层状羟基磷灰石（L-HAp-Se-Gd）。结果表明，与裸L-HAp相比，所制备的L-HAp-Se-Gd纳米粒子在形态、尺寸和结晶度方面呈现出明显变化。X射线衍射（XRD）结果显示，高掺杂水平的Se和Gd降低了HAp薄片的有序程度。研究发现，L-HAp-Se-Gd纳米粒子在紫外线（UV）照射下呈现出依赖于Gd含量的蓝色荧光以及磁性。用小鼠胚胎成骨细胞（MC3T3-E1）进行的细胞测试表明，由于掺入了Se，它们比裸L-HAp具有更好的生物相容性。这些结果表明，L-HAp-Se-Gd纳米粒子在多功能基因递送和生物成像等众多应用中具有潜力。
