Liu Min, Liu Hui, Sun Shufen, Li Xuejiao, Zhou Yanmin, Hou Zhiyao, Lin Jun
Department of PeriodontologyStomatological, Hospital, Jilin University , Changchun 130021, P. R. China.
Langmuir. 2014 Feb 4;30(4):1176-82. doi: 10.1021/la500131d. Epub 2014 Jan 24.
Porous hydroxyapatite (HAp) composite fibers functionalized with up-conversion (UC) luminescent and magnetic Na(Y/Gd)F4:Yb(3+),Er(3+) nanocrystals (NCs) have been fabricated via electrospinning. After transferring hydrophobic oleic acid-capped Na(Y/Gd)F4:Yb(3+),Er(3+) NCs into aqueous solution, these water-dispersible NCs were dispersed into precursor electrospun solution containing CTAB. Na(Y/Gd)F4:Yb(3+),Er(3+)@HAp composite fibers were fabricated by the high temperature treatment of the electrospun Na(Y/Gd)F4:Yb(3+),Er(3+) NCs decorated precursor fibers. The biocompatibility test on MC 3T3-E1 cells using MTT assay shows that the HAp composite fibers have negligible cytotoxity, which reveals the HAp composite fibers could be a drug carrier for drug delivery. Because the contrast brightening is enhanced at increased concentrations of Gd(3+), the HAp composite fibers can serve as T1 magnetic resonance imaging contrast agents. In addition, the composites uptaken by MC 3T3-E1 cells present the UC luminescent emission of Er(3+) under the excitation of a 980 nm near-infrared laser. The above findings reveal Na(Y/Gd)F4:Yb(3+),Er(3+)@HAp composite fibers have potential applications in drug storage/release and magnetic resonance/UC luminescence imaging.
通过静电纺丝制备了用发光上转换（UC）和磁性Na(Y/Gd)F4:Yb(3+),Er(3+)纳米晶体（NCs）功能化的多孔羟基磷灰石（HAp）复合纤维。将疏水油酸包覆的Na(Y/Gd)F4:Yb(3+),Er(3+) NCs转移到水溶液中后，将这些水分散性NCs分散到含有十六烷基三甲基溴化铵（CTAB）的静电纺丝前驱体溶液中。通过对装饰有Na(Y/Gd)F4:Yb(3+),Er(3+) NCs的静电纺丝前驱体纤维进行高温处理，制备了Na(Y/Gd)F4:Yb(3+),Er(3+)@HAp复合纤维。使用MTT法对MC 3T3-E1细胞进行的生物相容性测试表明，HAp复合纤维的细胞毒性可忽略不计，这表明HAp复合纤维可作为药物递送的药物载体。由于在Gd(3+)浓度增加时对比度增强，HAp复合纤维可作为T1磁共振成像造影剂。此外，被MC 3T3-E1细胞摄取的复合材料在980 nm近红外激光激发下呈现Er(3+)的UC发光发射。上述发现表明Na(Y/Gd)F4:Yb(3+),Er(3+)@HAp复合纤维在药物储存/释放以及磁共振/UC发光成像方面具有潜在应用。
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