Hu Mingxing, Yang Chao, Luo Yi, Chen Fan, Yang Fangfang, Yang Shuping, Chen Hao, Cheng Zhiqiang, Li Kun, Xie Yongmei
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province 610041, P. R. China.
J Mater Chem B. 2018 Apr 28;6(16):2413-2416. doi: 10.1039/c8tb00546j. Epub 2018 Apr 16.
Herein, a novel soluble mitochondria-targeted theranostic compound, HMX-1, was presented, which was selectively activated under hypoxia with excellent mitochondria-targeting ability at the cellular level, accompanied by a dramatic increase in the fluorescence intensity. Moreover, its anti-cancer efficiency was certified both in vitro and in vivo.
在此，我们展示了一种新型的可溶性线粒体靶向治疗诊断化合物HMX-1，它在缺氧条件下被选择性激活，在细胞水平上具有出色的线粒体靶向能力，同时荧光强度显著增加。此外，其抗癌效率在体外和体内均得到了验证。
