Kang Han Chang
Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662 Republic of Korea.
Biomater Res. 2018 Nov 8;22:34. doi: 10.1186/s40824-018-0145-7. eCollection 2018.
Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells.
With the necessity of subcellular organelle-targeting drug delivery and theranostics, examples of mitochondria-targeting moieties and types of mitochondria-targeting theranostics were introduced. In addition, the current studies of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems were summarized.
With the current issues of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems, their potentials and alternatives are discussed.
由于亚细胞器靶向药物递送对于最大化治疗效果和最小化副作用具有重要意义，以及诊疗一体化对于在整个诊断过程中以正确的位置和剂量递送治疗药物治疗疾病具有重要意义，对亚细胞器靶向诊疗一体化的兴趣正在大幅增加。在细胞器中，线粒体因其在细胞中的重要控制功能而受到了广泛关注。
鉴于亚细胞器靶向药物递送和诊疗一体化的必要性，介绍了线粒体靶向部分的实例以及线粒体靶向诊疗一体化的类型。此外，还总结了目前针对线粒体靶向诊疗化学物质、化学缀合物和纳米系统的研究。
针对目前线粒体靶向诊疗化学物质、化学缀合物和纳米系统存在的问题，讨论了它们的潜力和替代方案。
