Yao Jun, Zhu Chuanda, Peng Tianjiao, Ma Qiang, Gao Shegan
Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Front Bioeng Biotechnol. 2021 Dec 23;9:791891. doi: 10.3389/fbioe.2021.791891. eCollection 2021.
Recently, organic-inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (TiC) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate TiC nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The TiC nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, TiC nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of TiC nanoparticles. The and results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention and elevating the local temperature in tumors.
近年来，有机-无机杂化材料作为癌症治疗的有效光热剂备受关注。在本研究中，聚环氧乙烷-聚环氧丙烷-聚环氧乙烷三嵌段共聚物F127水凝胶包覆的碳化钛（TiC）纳米颗粒被用作可注射的光热剂。这些纳米颗粒的优点是绿色合成且光热效率优异。在该系统中，主要使用激光照射TiC纳米颗粒以产生恒定的高温，从而损伤癌细胞。发现这些纳米颗粒在低温储存至少2周期间是稳定的。TiC纳米颗粒呈现梭形结构，水凝胶呈现疏松的网状结构。此外，TiC纳米颗粒不影响凝胶的可逆温度敏感性，水凝胶也不影响TiC纳米颗粒的光热性能。 和 结果表明，该水凝胶系统在近红外照射下能有效抑制肿瘤生长，具有优异的生物相容性和生物安全性。嵌入光热剂的水凝胶通过增强滞留性和提高肿瘤局部温度，是一种有前途的癌症光热治疗策略。
