Du Xiaoyu, Fu Shengyang, Zhu Yufang
School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
J Mater Chem B. 2018 Jul 21;6(27):4397-4412. doi: 10.1039/c8tb00677f. Epub 2018 Jul 2.
Currently, one of the most promising strategies in bone tissue engineering focuses on the development of biomimetic scaffolds. Ceramic-based scaffolds with favorable osteogenic ability and mechanical properties are promising candidates for bone repair. Three-dimensional (3D) printing is an additive manufacturing technique, which allows the fabrication of patient-specific scaffolds with high structural complexity and design flexibility, and gains growing attention. This review aims to highlight advances in 3D printing of ceramic-based scaffolds for bone tissue engineering. Technical limitations and practical challenges are emphasized and design considerations are also discussed.
目前，骨组织工程中最具前景的策略之一聚焦于仿生支架的研发。具有良好成骨能力和机械性能的陶瓷基支架是骨修复的理想候选材料。三维（3D）打印是一种增材制造技术，它能够制造出具有高度结构复杂性和设计灵活性的个性化支架，因而越来越受到关注。本综述旨在突出用于骨组织工程的陶瓷基支架3D打印方面的进展。文中强调了技术局限性和实际挑战，并讨论了设计考量因素。
