Tamarov K, Näkki S, Xu W, Lehto V-P
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
J Mater Chem B. 2018 Jun 14;6(22):3632-3649. doi: 10.1039/c8tb00462e. Epub 2018 May 17.
The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common. The first issue to be considered with regard to the nanomaterials being utilized in medicine centers on their safety. The functionality of nanocarriers in real-life environments explains the enthusiasm for their use. Several functionalities are typically added onto nanocarriers but the most crucial feature of those carriers intended to be administered intravenously is that they should possess a long residence time in blood circulation. The present review focusses on the mesoporous nanoparticles due to their great promise in nanomedicine and concentrates on their coatings because it is the outmost layer which dictates their first interactions with the surroundings and often determines their biofate.
将各种无机纳米粒子用作药物载体和治疗剂的情况越来越普遍。在医学中使用纳米材料时首先要考虑的问题集中在其安全性上。纳米载体在实际环境中的功能解释了人们对其使用的热情。通常会在纳米载体上添加几种功能，但那些打算静脉给药的载体最关键的特征是它们在血液循环中应具有较长的停留时间。本综述聚焦于介孔纳米粒子，因为它们在纳米医学中有很大的前景，并着重关注其涂层，因为最外层决定了它们与周围环境的首次相互作用，并且常常决定它们的生物命运。
