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用于生物成像、靶向药物递送和治疗的无机纳米材料。

Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics.

作者信息

Liang Ruizheng, Wei Min, Evans David G, Duan Xue

机构信息

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

出版信息

Chem Commun (Camb). 2014 Nov 25;50(91):14071-81. doi: 10.1039/c4cc03118k.

Abstract

Inorganic nanomaterials including gold nanoparticles, mesoporous silica nanoparticles, graphene, magnetic nanoparticles, quantum dots and layered double hydroxides have become one of the most active research fields in biochemistry, biotechnology and biomedicine. Benefiting from the facile synthesis/modification, intrinsically physicochemical properties and good biocompatibility, inorganic nanomaterials have shown great potential in bioimaging, targeted drug delivery and cancer therapies. This Feature Article summarizes recent progress on various inorganic nanocarriers, including the background, synthesis, modification, cytotoxicity, physicochemical properties as well as their applications in biomedicine.

摘要

包括金纳米颗粒、介孔二氧化硅纳米颗粒、石墨烯、磁性纳米颗粒、量子点和层状双氢氧化物在内的无机纳米材料已成为生物化学、生物技术和生物医学中最活跃的研究领域之一。得益于简便的合成/修饰方法、内在的物理化学性质和良好的生物相容性,无机纳米材料在生物成像、靶向给药和癌症治疗方面显示出巨大潜力。这篇专题文章总结了各种无机纳米载体的最新进展,包括背景、合成、修饰、细胞毒性、物理化学性质及其在生物医学中的应用。

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