Yang Yongmei, Gong Baoyou, Yang Ying, Xie Anjian, Shen Yuhua, Zhu Manzhou
College of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, P. R. China.
J Mater Chem B. 2018 Jun 14;6(22):3792-3799. doi: 10.1039/c8tb00608c. Epub 2018 May 29.
A novel cabbage-like FeO@MoS@ZnO nanocomposite was successfully fabricated through a facile method. The as-prepared nanocomposite exhibited a saturation magnetization of 45 emu g as well as possessed a massive pore structure and large surface area, leading to a high DOX loading capacity of 68.14 μg mg; it could effectively deliver drugs to tumor lesion sites under the action of magnetic targeting. The pH-dependent ZnO as a packaging component can block the pores to achieve controlled release of DOX under tumor stimulation conditions (pH 6.5), thereby reducing the side effects of DOX on normal cells and increasing its therapy effects on tumor cells. Moreover, the photothermal conversion efficiency contributed by MoS under 808 nm NIR laser irradiation was utilized to realize effective photothermal therapy (PTT) of cancer, which could be integrated with chemotherapy in a single system. Thus, the resulting FeO@MoS@ZnO nanocomposites provide hopeful prospects in biomedical applications based on pH sensitivity, magnetic targeting and chemo-photothermal synergistic therapy.
通过一种简便的方法成功制备了一种新型的白菜状FeO@MoS@ZnO纳米复合材料。所制备的纳米复合材料表现出45 emu g的饱和磁化强度，同时具有大量的孔结构和大的表面积，导致阿霉素（DOX）的高负载量为68.14 μg mg；它可以在磁靶向作用下有效地将药物递送至肿瘤病变部位。作为封装成分的pH依赖性ZnO可以堵塞孔道，从而在肿瘤刺激条件（pH 6.5）下实现DOX的控释，进而减少DOX对正常细胞的副作用并提高其对肿瘤细胞的治疗效果。此外，利用在808 nm近红外激光照射下MoS贡献的光热转换效率实现癌症的有效光热治疗（PTT），其可以在单一系统中与化疗相结合。因此，所得的FeO@MoS@ZnO纳米复合材料基于pH敏感性、磁靶向和化学-光热协同治疗在生物医学应用中提供了有希望的前景。
