制备用于磁靶向和近红外响应化疗-光热联合治疗的rGO@FeO微球的简便方法
Facile Approach to Prepare rGO@FeO Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy.
作者信息
Liang Chunyong, Song Jiying, Zhang Yongguang, Guo Yaping, Deng Meigui, Gao Wei, Zhang Jimin
机构信息
Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science & Engineering, Hebei University of Technology, Tianjin, 300130, China.
Hebei Key Laboratory of Functional Polymers, National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, China.
出版信息
Nanoscale Res Lett. 2020 Apr 17;15(1):86. doi: 10.1186/s11671-020-03320-1.
Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of FeO-decorated hollow graphene microspheres (rGO@FeO) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (~ 120.7 m g) and large pore volume (~ 1.012 cm g), demonstrating distinct advantages for a high loading capacity of DOX (~ 18.43%). NIR triggered photothermal effect of the rGO@FeO microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The FeO on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@FeO/DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@FeO/DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.
近红外（NIR）光响应性石墨烯已在癌症光热消融治疗中展现出令人兴奋的效果。在此，我们报告通过简便的喷雾干燥和共沉淀法制备FeO修饰的中空石墨烯微球（rGO@FeO），用于磁靶向和近红外响应性化学-光热联合治疗。这些微球具有非常高的比表面积（约120.7 m²/g）和大孔体积（约1.012 cm³/g），显示出对阿霉素（DOX）的高负载能力（约18.43%）的明显优势。近红外触发的rGO@FeO微球的光热效应以开-关方式响应，并诱导出高的光热转换效率。此外，微球上的FeO表现出优异的肿瘤细胞靶向能力。基于rGO@FeO/DOX的化学-光热治疗在体外对Hela细胞显示出优异的细胞毒性。我们的研究表明，rGO@FeO/DOX微胶囊在化学-光热联合癌症治疗中具有巨大潜力。
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