Yang Ying, Wang Chen, Tian Chen, Guo Hailing, Shen Yuhua, Zhu Manzhou
College of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, P. R. China.
J Mater Chem B. 2018 Nov 14;6(42):6848-6857. doi: 10.1039/c8tb02077a. Epub 2018 Oct 12.
Considering traditional treatment methods, such as chemotherapy, with their potential side effects and lack of targeting, photodynamic therapy (PDT) and photothermal therapy (PTT), being innovative, with less side effects, and light-controlled strategies for antitumour applications, have received extensive attention, but the efficacy of PDT is seriously hindered by the hypoxia tumour microenvironment. Here, a multifunctional nanocomposite composed of an iron oxide (FeO) core and two shells of manganese dioxide (MnO) and polypyrrole (PPy) was successfully prepared and used to solve these issues. PPy, simultaneously as the photothermal agent and photosensitizer, was first combined with MnO to coat magnetic FeO for achieving an increase in the intracellular O concentration and to improve the generation ability of singlet oxygen upon laser irradiation, so that enhanced PDT/PTT could be obtained. After the efficient loading of doxorubicin (DOX) on the FeO@MnO@PPy nanocomposite, an acid controlled-release behaviour for DOX as well as magnetic-targeting-assisted synergistic effects of chemotherapy and improved PDT/PTT for tumour cells could be realized, which could also protect normal cells from damage. All these features may render our nanocomposite a promising platform to reverse hypoxia-triggered PDT resistance and chemotherapy-caused side effects in cancer therapy and other biomedical applications.
考虑到传统治疗方法，如化疗，存在潜在的副作用且缺乏靶向性，光动力疗法（PDT）和光热疗法（PTT）作为创新的、副作用较小的抗肿瘤应用光控策略，受到了广泛关注，但PDT的疗效受到肿瘤缺氧微环境的严重阻碍。在此，成功制备了一种由氧化铁（FeO）核以及二氧化锰（MnO）和聚吡咯（PPy）两层壳组成的多功能纳米复合材料，用于解决这些问题。PPy同时作为光热剂和光敏剂，首先与MnO结合包覆磁性FeO，以提高细胞内O浓度，并增强激光照射下单线态氧的生成能力，从而实现增强的PDT/PTT。在FeO@MnO@PPy纳米复合材料上高效负载阿霉素（DOX）后，可实现DOX的酸控释行为以及化疗的磁靶向辅助协同效应，并改善对肿瘤细胞的PDT/PTT，同时还能保护正常细胞免受损伤。所有这些特性可能使我们的纳米复合材料成为一个有前景的平台，用于逆转癌症治疗及其他生物医学应用中缺氧引发的PDT耐药性和化疗引起的副作用。
