Rehman Fawad Ur, Jiang Hui, Selke Matthias, Wang Xuemei
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Sipailou 2, Nanjing 210096, Jiangsu, People's Republic of China.
J Mater Chem B. 2018 Nov 7;6(41):6501-6514. doi: 10.1039/c8tb01955j. Epub 2018 Sep 26.
Production of nanoscale materials often requires the use of toxic chemicals and complex synthetic procedures. A new scaffold has been explored for in situ synthesis of nanomaterials that utilizes natural biological systems in the form of plants, bacteria, fungi, algae and redox-imbalanced mammalian cells and systems. The latter approach has become popular in recent years and has shown some promising results in bioimaging of cancer, as well as inflammatory and neurodegenerative maladies. Biosynthesis of nanoclusters in redox-imbalanced mammalian cells is facile, cost-effective and environmentally friendly with higher biocompatibility and target specificity and lower adverse effects than traditional synthetic approaches. Herein, we describe recent advances in mammalian green in situ biosynthesis for biomedical applications, especially in cancer and neurodegenerative disease theranostics.
纳米级材料的生产通常需要使用有毒化学品和复杂的合成程序。人们探索了一种新的支架用于纳米材料的原位合成，该支架利用植物、细菌、真菌、藻类和氧化还原失衡的哺乳动物细胞及系统等天然生物系统。后一种方法近年来已变得流行，并在癌症、炎症和神经退行性疾病的生物成像方面显示出一些有前景的结果。与传统合成方法相比，在氧化还原失衡的哺乳动物细胞中生物合成纳米团簇简便、经济高效且环境友好，具有更高的生物相容性和靶向特异性以及更低的副作用。在此，我们描述了用于生物医学应用，特别是癌症和神经退行性疾病诊疗的哺乳动物绿色原位生物合成的最新进展。
