Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
J Mater Chem B. 2019 Mar 7;7(9):1404-1414. doi: 10.1039/c8tb02504e. Epub 2019 Feb 4.
A novel nano-CaCO (nCaCO) particle composite-derived polystyrene (PS) resin was successfully synthesized by a suspension polymerization method. The nCaCO reinforced PS material (PS/nCaCO) possessed a structure with abundant mesopores of high porosity, high specific surface area (828.3 m g) and large pore volume (1.83 cm g). It was revealed that the incorporation of nCaCO into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, M = 24.0 kDa) from human plasma. The adsorption isotherm could be described by the Langmuir model and classified as S-3 type, showing an IL-6 uptake of up to 25.6 ng g at an equilibrium concentration of about 500 ng L. The adsorption capacity for IL-6 of PS/nCaCO is not only significantly higher than that of PS (without nCaCO), but also superior to those of currently available adsorbents that are under clinical studies (e.g., CytoSorb™ towards cytokines). In addition, the PS/nCaCO adsorbent also had good hemocompatibility and showed no leakage of nCaCO in the plasma in a flowing model system. Therefore, the synthesized PS/nCaCO nano-composite has a great potential to be used as an efficient adsorbent for the removal of interleukin-6 (IL-6) from blood of inflammatory and auto-immune disease patients through hemoperfusion.
采用悬浮聚合法成功合成了一种新型纳米碳酸钙（nCaCO）粒子复合材料衍生的聚苯乙烯（PS）树脂。nCaCO 增强 PS 材料（PS/nCaCO）具有丰富的中孔高孔隙率、高比表面积（828.3 m²/g）和大孔体积（1.83 cm³/g）的结构。研究表明，nCaCO 的掺入增强了 PS 基体的机械强度，防止了碎片的形成，并提高了其对人血浆中白细胞介素-6（IL-6，M = 24.0 kDa）的吸附能力。吸附等温线可以用朗缪尔模型描述，并归类为 S-3 型，在约 500 ng/L 的平衡浓度下，IL-6 的吸附量高达 25.6 ng/g。PS/nCaCO 对 IL-6 的吸附能力不仅明显高于 PS（不含 nCaCO），而且优于目前正在临床研究中的吸附剂（例如，CytoSorb™ 对细胞因子）。此外，PS/nCaCO 吸附剂在流动模型系统中也具有良好的血液相容性，在血浆中没有 nCaCO 的泄漏。因此，合成的 PS/nCaCO 纳米复合材料具有很大的潜力，可作为一种有效的吸附剂，通过血液灌流从炎症和自身免疫性疾病患者的血液中去除白细胞介素-6（IL-6）。
