Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia.
School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
Small Methods. 2021 May 12;5(5):e2001108. doi: 10.1002/smtd.202001108. Epub 2021 Jan 18.
During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D TiCT MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID-19 patients.
在全球 COVID-19 大流行期间，“细胞因子风暴”被认为是导致大多数患者死亡的致命步骤。血液灌流被广泛用于从重病患者的血液中清除细胞因子，以防止细胞因子风暴引发的失控炎症。本文首次发现，二维 TiCT MXene 片对典型细胞因子白细胞介素-6 具有超高的去除能力。具体来说，MXene 对细胞因子白细胞介素-6 的去除效率比传统的活性炭吸附剂高出 13.4 倍。分子水平的研究表明，MXene 表现出一种强大的化学吸附机制，用于固定细胞因子白细胞介素-6 分子，这与活性炭吸附剂不同。MXene 片还表现出优异的血液相容性，对人体血液成分没有任何不良影响。这项工作为使用 MXene 片作为超高效血液灌流吸附剂来消除严重 COVID-19 患者的细胞因子风暴综合征开辟了新途径。
