Hu Gaofei, Yang Lili, Li Yina, Wang Leyu
State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
J Mater Chem B. 2018 Dec 21;6(47):7936-7942. doi: 10.1039/c8tb02308e. Epub 2018 Nov 14.
Metal-organic frameworks (MOFs) have been widely used for drug/dye loading, but the large scale continuous production of these nanoparticles with good stability and biocompatibility still faces great challenges. Herein, a thermal-assisted microfluidic system was developed for the continuous and scalable fabrication of drug loaded MOFs@SiO nanoparticles with uniform shape, narrow size distribution, good stability and excellent biocompatibility. This facile and general strategy is readily employed in the encapsulation of many dyes and drugs. In vivo photodynamic therapy for cancers, based on rose bengal-loaded nanoparticles, demonstrates the great potential of this novel fabrication strategy in biomedical fields.
金属有机框架材料（MOFs）已被广泛用于药物/染料负载，但大规模连续生产具有良好稳定性和生物相容性的这些纳米颗粒仍面临巨大挑战。在此，开发了一种热辅助微流控系统，用于连续且可扩展地制备形状均匀、尺寸分布窄、稳定性好且生物相容性优异的载药MOFs@SiO纳米颗粒。这种简便通用的策略很容易用于许多染料和药物的封装。基于负载孟加拉玫瑰红的纳米颗粒的癌症体内光动力疗法证明了这种新型制备策略在生物医学领域的巨大潜力。
