Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.
J Mater Chem B. 2019 Mar 21;7(11):1842-1846. doi: 10.1039/c8tb02276c. Epub 2019 Feb 13.
We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE mice.
我们将一种具有生物相容性的植物病毒纳米技术(烟草花叶病毒,TMV)与 S100A9 靶向肽结合,将其应用于动脉粥样硬化的成像和诊断。S100A9 靶向 TMV 纳米颗粒对 S100A9 表现出显著的特异性,并能靶向 ApoE 小鼠的动脉粥样硬化病变。