S100A9 靶向的烟草花叶病毒纳米颗粒对 ApoE 小鼠的动脉粥样硬化病变具有高特异性。
S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE mice.
机构信息
Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
J Mater Chem B. 2019 Mar 21;7(11):1842-1846. doi: 10.1039/c8tb02276c. Epub 2019 Feb 13.
Abstract
We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE mice.
摘要
我们将一种具有生物相容性的植物病毒纳米技术（烟草花叶病毒，TMV）与 S100A9 靶向肽结合，将其应用于动脉粥样硬化的成像和诊断。S100A9 靶向 TMV 纳米颗粒对 S100A9 表现出显著的特异性，并能靶向 ApoE 小鼠的动脉粥样硬化病变。
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