Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
J Mater Chem B. 2019 Feb 14;7(6):994-1004. doi: 10.1039/c8tb02815j. Epub 2019 Jan 23.
Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for the preparation of stimuli-responsive multifunctional MOFs. We show that the combination of a versatile coating material polydopamine with MOFs enables facile integration of different functional therapeutics, obtaining stimuli-responsive multifunctional MOFs with extensive photothermal efficiency and outstanding capability to abrogate tumors by chemo-photothermal therapy. Exemplary MOFs including ZIF-8, UiO-66, and MIL-101 were utilized to prepare stimuli-responsive multifunctional MOFs to illustrate the generality of the strategy. This approach enables targeted drug delivery and stimuli-responsive release of multi-therapeutics and allows combination therapy with excellent in vitro and in vivo antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.
构建对刺激响应的多功能纳米粒子对于纳米治疗药物输送至关重要。尽管金属-有机骨架（MOFs）已成为有前途的输送载体，但 MOFs 在癌症治疗中的治疗效果受到缺乏制备对刺激响应的多功能 MOFs 的通用方法的限制。我们表明，多功能涂层材料聚多巴胺与 MOFs 的结合能够轻松地整合不同的功能疗法，获得对刺激响应的多功能 MOFs，具有广泛的光热效率和通过化学-光热疗法消除肿瘤的出色能力。利用代表性的 MOFs 包括 ZIF-8、UiO-66 和 MIL-101 来制备对刺激响应的多功能 MOFs，以说明该策略的通用性。这种方法能够实现靶向药物输送和多功能药物的刺激响应释放，并允许与具有优异的体外和体内抗肿瘤活性的联合疗法相结合。考虑到 MOFs 和不同功能分子的多样性，这项工作为可编程 MOF 纳米粒子提供了灵活的途径，适用于特定的生物应用。
