胆固醇水平为多发性骨髓瘤患者提供预后信息。

Cholesterol Levels Provide Prognostic Information in Patients with Multiple Myeloma.

出版信息

Clin Lab. 2020 Apr 1;66(4). doi: 10.7754/Clin.Lab.2019.190824.

DOI:10.7754/Clin.Lab.2019.190824

Abstract

BACKGROUND

Hypocholesterolemia has been reported to be associated with cancer risk and progression. The aim of this retrospective study was to investigate the prognostic value of cholesterol levels in patients with multiple myeloma (MM).

METHODS

A total of 153 patients newly diagnosed with MM were retrospectively enrolled. The relationship between cholesterol levels and clinical characteristics was evaluated. The prognostic value of cholesterol levels was explored.

RESULTS

The levels of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides (TC) were significantly lower in MM patients (p < 0.001). What is more, multivariate analyses showed that low TC and LDL-c levels were independent predictors of a better OS (overall survival; HR = 6.893 and 0.204; CI = 1.135 - 41.868 and 0.045 - 0.930, p = 0.036 and 0.040) and PFS (progression-free survival; HR = 7.416 and 0.216; CI = 1.365 - 40.290 and 0.047 - 0.999, p = 0.020 and 0.049).

CONCLUSIONS

Serum cholesterol levels in MM patients were low, and TC and LDL-c levels could be used as prognostic markers for MM patients.

摘要

背景

低胆固醇血症与癌症风险和进展有关。本回顾性研究旨在探讨多发性骨髓瘤（MM）患者胆固醇水平的预后价值。

方法

共回顾性纳入 153 例新诊断为 MM 的患者。评估胆固醇水平与临床特征的关系。探讨胆固醇水平的预后价值。

结果

MM 患者的低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯（TC）水平显著降低（p<0.001）。多变量分析显示，低 TC 和 LDL-c 水平是总生存期（OS；HR=6.893 和 0.204；CI=1.135-41.868 和 0.045-0.930，p=0.036 和 0.040）和无进展生存期（PFS；HR=7.416 和 0.216；CI=1.365-40.290 和 0.047-0.999，p=0.020 和 0.049）的独立预后因素。