miR-146a 多态性与胃癌风险的关联：一项荟萃分析。

Association between the miR-146a Polymorphisms and the Risk of Gastric Cancer: a Meta-Analysis.

出版信息

Clin Lab. 2020 Apr 1;66(4). doi: 10.7754/Clin.Lab.2019.190921.

DOI:10.7754/Clin.Lab.2019.190921

Abstract

BACKGROUND

Published data regarding associations between the microRNA-146a polymorphism and the risk of gastric cancer are inconclusive. This study aims at evaluating the genetic risk of microRNA-146a polymorphism in gastric cancer.

METHODS

A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 15th, 2019). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software.

RESULTS

A total of 5,017 cases and 4,869 controls in 14 case-control studies were included in this meta-analysis. No significant association between microRNA-146a polymorphism and gastric cancer risk was observed in all kinds of genetic models (homozygote genetic model CC vs. GG: OR = 0.96, 95% CI = 0.81 - 1.15, p = 0.66; the heterozygote genetic model CG vs. GG: OR = 0.94, 95% CI = 0.86 - 1.02, p = 0.15; the recessive genetic model CC vs. CG + GG: OR = 0.98, 95% CI = 0.91 - 1.05; the dominant genetic model CC + CG vs. GG: OR = 0.94, 95% CI = 0.86 - 1.01, p = 0.1, p = 0.55; and the allele genetic model C vs. G: OR = 0.98, 95% CI = 0.89 - 1.06, p = 0.58). In subgroup analysis, the C allele may be a protective factor for gastric cancer development in the analysis of the dominant genetic model (CC + CG vs. GG) in HCC studies (OR = 0.90, 95% CI = 0.83 - 0.98, p = 0.02) but a risk factor in Japanese when calculated with the recessive genetic model (CC vs. CG + GG) (OR = 1.19, 95% CI = 1.02 - 1.40, p = 0.03).

CONCLUSIONS

Based on our meta-analysis, the microRNA-146a polymorphism is unlikely to be a risk factor for gastric cancer in overall population.

摘要

背景

关于 microRNA-146a 多态性与胃癌风险之间的关联，已有文献报道结果并不一致。本研究旨在评估 microRNA-146a 多态性与胃癌遗传风险的关系。

方法

系统检索 Pubmed、Medline（Ovid）、Embase、CBM、CNKI、维普、万方数据库，全面收集 microRNA-146a 多态性与胃癌关系的相关文献，检索时限均从建库至 2019 年 4 月 15 日。采用 Revman 5.2 和 STATA 10.1 软件进行数据分析。

结果

共纳入 14 项病例对照研究的 5017 例病例和 4869 例对照。在各种遗传模型中，microRNA-146a 多态性与胃癌风险均无显著相关性（同型遗传模型 CC 与 GG：OR = 0.96，95%CI = 0.81 - 1.15，p = 0.66；杂合遗传模型 CG 与 GG：OR = 0.94，95%CI = 0.86 - 1.02，p = 0.15；隐性遗传模型 CC 与 CG + GG：OR = 0.98，95%CI = 0.91 - 1.05；显性遗传模型 CC + CG 与 GG：OR = 0.94，95%CI = 0.86 - 1.01，p = 0.10，p = 0.55；等位基因遗传模型 C 与 G：OR = 0.98，95%CI = 0.89 - 1.06，p = 0.58）。亚组分析显示，在 HCC 研究中显性遗传模型（CC + CG 与 GG）中，C 等位基因可能是胃癌发病的保护因素（OR = 0.90，95%CI = 0.83 - 0.98，p = 0.02），而在日本人群中隐性遗传模型（CC 与 CG + GG）中则为危险因素（OR = 1.19，95%CI = 1.02 - 1.40，p = 0.03）。