基于24项研究的更新：微小RNA-146a rs2910164 G>C多态性与自身免疫性疾病易感性关联的荟萃分析
Meta-analysis of microRNA-146a rs2910164 G>C polymorphism association with autoimmune diseases susceptibility, an update based on 24 studies.
作者信息
Li Changzheng, Fu Weijun, Zhang Yu, Zhou Liang, Mao Zhi, Lv Weiran, Li Juan, Zhou Ye
机构信息
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
出版信息
PLoS One. 2015 Apr 1;10(4):e0121918. doi: 10.1371/journal.pone.0121918. eCollection 2015.
BACKGROUND
Published data showed that the susceptibility of autoimmune diseases (ADs) was associated with the polymorphism rs2910164 in microRNA-146a (miR-146a). However, the results remain controversial so far. Two meta-analyses published in 2013 and 2014 came to opposite conclusions. In order to derive a more precise estimation of the relationship, we performed this meta-analysis.
METHODS
We searched the PubMed, OvidSP and CNKI databases (published prior to September 8th, 2014) and extracted data from eligible studies. The procedure of meta-analysis was performed by using the Stata 12.0 software. Random effect model or fixed effect model were chosen respectively, according to the between study heterogeneities.
RESULTS
A total of 24 case-control studies, 11 more than previous meta-analysis on this topic, were involved. We took stratified analyses by different ethnicities and different types of diseases in different genetic models. In Caucasian subgroup, significant increased risks of GC genotype and GC+CC genotype with ADs susceptibility were found in heterozygote model (GC vs GG, OR = 1.38, 95% CI 1.04-1.83, p = 0.024) and dominant model (GC+CC vs GG, OR = 1.37, 95% CI 1.01-1.85, p = 0.041), respectively. Meanwhile, in other disease subgroup, significant increased risks of C allele, CC genotype and GC+CC genotype were found in allele model (C vs G, OR = 1.16, 95% CI 1.04-1.31, p = 0.010), homozygote model (CC vs GG, OR = 1.42, 95% CI 1.10-1.84, p = 0.006) and dominant model (GC+CC vs GG, OR = 1.25, 95% CI 1.04-1.51, p = 0.020), respectively.
CONCLUSIONS
MiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs.
背景
已发表的数据表明，自身免疫性疾病（ADs）的易感性与微小RNA-146a（miR-146a）中的rs2910164多态性相关。然而，目前结果仍存在争议。2013年和2014年发表的两项荟萃分析得出了相反的结论。为了更精确地评估二者关系，我们进行了此项荟萃分析。
方法
检索了PubMed、OvidSP和CNKI数据库（截至2014年9月8日发表的文献），并从符合条件的研究中提取数据。荟萃分析过程使用Stata 12.0软件进行。根据研究间的异质性分别选择随机效应模型或固定效应模型。
结果
共纳入24项病例对照研究，比之前关于该主题的荟萃分析多11项。我们在不同遗传模型中按不同种族和不同疾病类型进行了分层分析。在白种人亚组中，杂合子模型（GC与GG相比，OR = 1.38，95%CI 1.04 - 1.83，p = 0.024）和显性模型（GC + CC与GG相比，OR = 1.37，95%CI 1.01 - 1.85，p = 0.041）中，分别发现GC基因型和GC + CC基因型与ADs易感性的风险显著增加。同时，在其他疾病亚组中，等位基因模型（C与G相比，OR = 1.16，95%CI 1.04 - 1.31，p = 0.010）、纯合子模型（CC与GG相比，OR = 1.42，95%CI 1.10 - 1.84，p = 0.006）和显性模型（GC + CC与GG相比，OR = 1.25，95%CI 1.04 - 1.51，p = 0.020）中，分别发现C等位基因、CC基因型和GC + CC基因型的风险显著增加。
结论
MiR-146a rs2910164 G>C多态性与ADs的易感性相关。
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