Crystal Engineering, Growth and Design Laboratory, Department of Chemistry, University of Crete, Heraklion, Crete, GR-71003, Greece.
Biochemistry Laboratory, Department of Chemistry, University of Crete, Heraklion, Crete, GR-71003, Greece.
Chem Commun (Camb). 2020 May 11;56(38):5166-5169. doi: 10.1039/d0cc00439a. Epub 2020 Apr 7.
In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (e.g. Ca and Mg) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
本文报道了基于膦酸酯 MOF 的药物传递系统。这些系统采用生物可接受的金属离子（如 Ca 和 Mg）和几种抗骨质疏松双膦酸盐药物（依替膦酸、帕米膦酸、阿仑膦酸和奈立膦酸）作为有机连接体。这些材料已经被合成、结构表征，并研究了它们在自牺牲释放（通过 pH 驱动的溶解）双膦酸盐活性成分的性能。它们的释放速率和最终的%释放率因金属-双膦酸盐材料的实际结构而异。它们的细胞毒性谱与活性成分相匹配。
