• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与皮肤鳞状细胞癌进展相关的重要生物标志物的鉴定

Significant Biomarkers Identification Associated with Cutaneous Squamous Cell Carcinoma Progression.

作者信息

Qiu Cheng-Gang, Shen Bin, Sun Xiao-Qi

机构信息

Department of Burn, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, 311200, Zhejiang, People's Republic of China.

Department of Plastic Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, 311200, Zhejiang, People's Republic of China.

出版信息

Int J Gen Med. 2022 Mar 2;15:2347-2360. doi: 10.2147/IJGM.S357022. eCollection 2022.

DOI:10.2147/IJGM.S357022
PMID:35264873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8901050/
Abstract

BACKGROUND

This study aimed to identify significant genes associated with cutaneous squamous cell carcinoma (CSCC) initiation and development.

METHODS

The overlapped differential expressed genes (DEGs) between normal and CSCC samples were firstly screened out, followed by KEGG analysis. The top 10 hub genes were then detected from the whole protein-protein interaction (PPI) network. Further, important biomarkers continuously associated with actinic keratosis (AK), CSCC, and CSCC invasion was successively filtrated. GSEA analysis was finally performed to reveal potential mechanisms associated with biomarkers.

RESULTS

A total of 179 DEGs were identified, which were enriched in pathways in cancer, PI3K-Akt signaling pathway, and human papillomavirus infection. The 10 hub genes were firstly identified from the PPI network, and they were all highly expressed in AK tissues compared with normal tissues. Next, we found that 6 genes were overexpressed in CSCC compared with AK tissues. Further, we identified that the expression of 2 genes (MYBL2 and TK1) was higher in CSCC invasion groups compared with samples without invasion. Through a series of filtrations, we confirmed that MYBL2 and TK1 were the most significant biomarkers associated with CSCC initiation and progression. The pan-cancer analysis further supported their prognostic value in human cancers. GSEA analysis found that they positively correlated with N glycan biosynthesis and p53 signaling pathways.

CONCLUSION

MYBL2 and TK1 were proved to play a vital role in CSCC tumorigenesis and progression, which may act as promising biomarkers or therapeutic targets for accurate diagnosis and treatment of CSCC.

摘要

背景

本研究旨在鉴定与皮肤鳞状细胞癌（CSCC）起始和发展相关的重要基因。

方法

首先筛选出正常样本与CSCC样本之间的重叠差异表达基因（DEG），随后进行KEGG分析。然后从整个蛋白质-蛋白质相互作用（PPI）网络中检测出前10个枢纽基因。此外，依次筛选出与光化性角化病（AK）、CSCC及CSCC侵袭持续相关的重要生物标志物。最后进行基因集富集分析（GSEA）以揭示与生物标志物相关的潜在机制。

结果

共鉴定出179个DEG，这些基因富集于癌症通路、PI3K-Akt信号通路和人乳头瘤病毒感染。首先从PPI网络中鉴定出10个枢纽基因，与正常组织相比，它们在AK组织中均高表达。接下来，我们发现与AK组织相比，6个基因在CSCC中过表达。进一步地，我们鉴定出与无侵袭样本相比，2个基因（MYBL2和TK1）在CSCC侵袭组中表达更高。通过一系列筛选，我们证实MYBL2和TK1是与CSCC起始和进展相关的最显著生物标志物。泛癌分析进一步支持了它们在人类癌症中的预后价值。GSEA分析发现它们与N-聚糖生物合成和p53信号通路呈正相关。

结论

已证明MYBL2和TK1在CSCC肿瘤发生和进展中起关键作用，它们可能作为有前景的生物标志物或治疗靶点用于CSCC的准确诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/890350fb337b/IJGM-15-2347-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/20b41fc10d24/IJGM-15-2347-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/f0232c67d28c/IJGM-15-2347-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/8319c65d808d/IJGM-15-2347-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/af9e5cf77315/IJGM-15-2347-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/bb2f8e8b892b/IJGM-15-2347-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/96b3001e831d/IJGM-15-2347-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/70e6c070b9f6/IJGM-15-2347-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/61eb1e32e3ee/IJGM-15-2347-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/68c5f969eb8b/IJGM-15-2347-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/14c59e48e535/IJGM-15-2347-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/089be308749d/IJGM-15-2347-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/890350fb337b/IJGM-15-2347-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/20b41fc10d24/IJGM-15-2347-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/f0232c67d28c/IJGM-15-2347-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/8319c65d808d/IJGM-15-2347-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/af9e5cf77315/IJGM-15-2347-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/bb2f8e8b892b/IJGM-15-2347-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/96b3001e831d/IJGM-15-2347-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/70e6c070b9f6/IJGM-15-2347-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/61eb1e32e3ee/IJGM-15-2347-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/68c5f969eb8b/IJGM-15-2347-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/14c59e48e535/IJGM-15-2347-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/089be308749d/IJGM-15-2347-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8901050/890350fb337b/IJGM-15-2347-g0012.jpg

相似文献

1
Significant Biomarkers Identification Associated with Cutaneous Squamous Cell Carcinoma Progression.与皮肤鳞状细胞癌进展相关的重要生物标志物的鉴定
Int J Gen Med. 2022 Mar 2;15:2347-2360. doi: 10.2147/IJGM.S357022. eCollection 2022.
2
Identification of key genes in cutaneous squamous cell carcinoma: a transcriptome sequencing and bioinformatics profiling study.皮肤鳞状细胞癌关键基因的鉴定：一项转录组测序与生物信息学分析研究
Ann Transl Med. 2021 Oct;9(19):1497. doi: 10.21037/atm-21-3915.
3
Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma.基于基因共表达网络分析鉴定的皮肤鳞状细胞癌 7 个关键枢纽基因
BMC Cancer. 2021 Jul 23;21(1):852. doi: 10.1186/s12885-021-08604-y.
4
Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma.单细胞测序凸显光化性角化病和皮肤鳞状细胞癌的异质性和恶性进展。
Elife. 2023 Dec 15;12:e85270. doi: 10.7554/eLife.85270.
5
Identification of potential gene drivers of cutaneous squamous cell carcinoma: Analysis of microarray data.皮肤鳞状细胞癌潜在基因驱动因素的鉴定：微阵列数据分析
Medicine (Baltimore). 2020 Sep 25;99(39):e22257. doi: 10.1097/MD.0000000000022257.
6
Gene Expression Patterns of Cutaneous Squamous Cell Carcinoma and Actinic Keratosis: Biomarkers Screening for Skin Disease Diagnosis.皮肤鳞状细胞癌和光化性角化病的基因表达模式：用于皮肤病诊断的生物标志物筛选
Ann Dermatol. 2018 Oct;30(5):536-543. doi: 10.5021/ad.2018.30.5.536. Epub 2018 Aug 28.
7
Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma.与光化性角化病进展为皮肤鳞状细胞癌相关的致病基因。
Int J Dermatol. 2018 Oct;57(10):1208-1217. doi: 10.1111/ijd.14131. Epub 2018 Aug 13.
8
Identification of as a candidate marker in cutaneous squamous cell carcinoma by integrated bioinformatics analysis.通过综合生物信息学分析鉴定某物质作为皮肤鳞状细胞癌的候选标志物。 （注：原文中“Identification of as a candidate marker”这里少了具体要鉴定的对象，我按照常规翻译补上了“某物质”，你可根据实际情况修改。）
Transl Cancer Res. 2021 Jan;10(1):469-478. doi: 10.21037/tcr-20-2945.
9
From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses.从 Bowen 病到皮肤鳞状细胞癌：通过转录组学和蛋白质组学分析验证了 8 个标志物。
J Transl Med. 2022 Sep 9;20(1):416. doi: 10.1186/s12967-022-03622-1.
10
Identifying an lncRNA-Related ceRNA Network to Reveal Novel Targets for a Cutaneous Squamous Cell Carcinoma.识别与长链非编码RNA相关的竞争性内源RNA网络以揭示皮肤鳞状细胞癌的新靶点
Biology (Basel). 2021 May 13;10(5):432. doi: 10.3390/biology10050432.

引用本文的文献

1
Electrochemical and Optical Carbon Dots and Glassy Carbon Biosensors: A Review on Their Development and Applications in Early Cancer Detection.电化学与光学碳点及玻碳生物传感器：关于其在早期癌症检测中的发展与应用综述
Micromachines (Basel). 2025 Jan 25;16(2):139. doi: 10.3390/mi16020139.
2
Strategic approaches in oral squamous cell carcinoma diagnostics using liquid biopsy.液体活检在口腔鳞状细胞癌诊断中的策略方法。
Periodontol 2000. 2024 Oct;96(1):316-328. doi: 10.1111/prd.12567. Epub 2024 Apr 27.
3
Utilizing systems genetics to enhance understanding into molecular targets of skin cancer.

本文引用的文献

1
Factors associated with inoperable cutaneous squamous cell carcinoma.与不可手术的皮肤鳞状细胞癌相关的因素。
Eur J Dermatol. 2021 Jun 1;31(3):396-402. doi: 10.1684/ejd.2021.4048.
2
Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma.基于基因共表达网络分析鉴定的皮肤鳞状细胞癌 7 个关键枢纽基因
BMC Cancer. 2021 Jul 23;21(1):852. doi: 10.1186/s12885-021-08604-y.
3
The landscape of driver mutations in cutaneous squamous cell carcinoma.皮肤鳞状细胞癌中驱动突变的情况
利用系统遗传学增进对皮肤癌分子靶点的理解。
Exp Dermatol. 2024 Mar;33(3):e15043. doi: 10.1111/exd.15043.
4
Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.淀粉样前体样蛋白 2 表达在皮肤鳞状细胞癌发病机制中的意义。
In Vivo. 2024 Jan-Feb;38(1):399-408. doi: 10.21873/invivo.13452.
5
Targeting receptor tyrosine kinase signaling: Avenues in the management of cutaneous squamous cell carcinoma.靶向受体酪氨酸激酶信号传导：皮肤鳞状细胞癌的治疗途径
iScience. 2023 May 5;26(6):106816. doi: 10.1016/j.isci.2023.106816. eCollection 2023 Jun 16.
6
Advances in Cutaneous Squamous Cell Carcinoma Management.皮肤鳞状细胞癌治疗进展
Cancers (Basel). 2022 Jul 27;14(15):3653. doi: 10.3390/cancers14153653.
NPJ Genom Med. 2021 Jul 16;6(1):61. doi: 10.1038/s41525-021-00226-4.
4
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.头颈部高危皮肤鳞状细胞癌：临床综述。
Ann Surg Oncol. 2021 Dec;28(13):9009-9030. doi: 10.1245/s10434-021-10108-9. Epub 2021 Jun 30.
5
Identifying an lncRNA-Related ceRNA Network to Reveal Novel Targets for a Cutaneous Squamous Cell Carcinoma.识别与长链非编码RNA相关的竞争性内源RNA网络以揭示皮肤鳞状细胞癌的新靶点
Biology (Basel). 2021 May 13;10(5):432. doi: 10.3390/biology10050432.
6
Identification of potential gene drivers of cutaneous squamous cell carcinoma: Analysis of microarray data.皮肤鳞状细胞癌潜在基因驱动因素的鉴定：微阵列数据分析
Medicine (Baltimore). 2020 Sep 25;99(39):e22257. doi: 10.1097/MD.0000000000022257.
7
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.转移性皮肤鳞状细胞癌的危险因素及预后：一项队列研究
Acta Derm Venereol. 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628.
8
Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland.芬兰 774 例患者中复发性和转移性皮肤鳞状细胞癌的队列研究。
Acta Derm Venereol. 2020 Apr 21;100(8):adv00121. doi: 10.2340/00015555-3479.
9
Advanced cutaneous squamous cell carcinoma: how is it defined and what new therapeutic approaches are available?高级别皮肤鳞状细胞癌：如何定义它，以及有哪些新的治疗方法？
Curr Opin Oncol. 2019 Sep;31(5):461-468. doi: 10.1097/CCO.0000000000000566.
10
Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR.长链非编码 RNA LINC00520 通过下调 EGFR 使 PI3K/Akt 信号通路失活，从而阻止皮肤鳞状细胞癌的进展。
Chin Med J (Engl). 2019 Feb;132(4):454-465. doi: 10.1097/CM9.0000000000000070.