Department of Dermatology and Allergology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, FIN-33521 Tampere, Finland.
Acta Derm Venereol. 2019 Apr 1;99(4):412-416. doi: 10.2340/00015555-3110.
The incidence of cutaneous squamous cell carcinoma is increasing worldwide. In most epidemiological studies, only the first case of cutaneous squamous cell carcinoma is registered, underestimating the burden of the disease. To determine the frequency and detailed characteristics of cutaneous squamous cell carcinoma in a Finnish patient cohort, we performed a retrospective 10-year study taking into account multiple tumours in one patient. On the pathology database search and medical record review we identified 774 patients with a total of 1,131 cutaneous squamous cell carcinomas. The crude incidence increased from 18.6/100,000 persons in 2006 to 28.1 in 2015. The location of tumours differed between men and women: the greatest difference concerned cutaneous squamous cell carcinoma of the ear, with 93% of cases occurring in men. One fourth (24%) of patients had more than one tumour. A small shift from poorly to well-differentiated tumours was seen. In conclusion, the incidence of cutaneous squamous cell carcinoma increased, with many patients presenting with multiple tumours.
皮肤鳞状细胞癌的发病率在全球范围内呈上升趋势。在大多数流行病学研究中，仅登记了第一例皮肤鳞状细胞癌，从而低估了该疾病的负担。为了确定芬兰患者队列中皮肤鳞状细胞癌的频率和详细特征，我们进行了一项回顾性的 10 年研究，考虑了一个患者中的多个肿瘤。我们通过对病理数据库的搜索和病历回顾，共确定了 774 例患者，总计有 1131 例皮肤鳞状细胞癌。粗发病率从 2006 年的 18.6/100,000 人增加到 2015 年的 28.1。肿瘤的位置在男性和女性之间存在差异：最大的差异是耳部皮肤鳞状细胞癌，其中 93%的病例发生在男性。四分之一（24%）的患者有多个肿瘤。从低分化到高分化肿瘤的微小转变可见一斑。总之，皮肤鳞状细胞癌的发病率上升，许多患者表现为多发性肿瘤。
