Mutoh T, Nishimura R, Kim H, Matsunaga S, Kadosawa T, Mochizuki M, Sasaki N
Department of Veterinary Surgery, University of Tokyo, Japan.
J Vet Med Sci. 1995 Dec;57(6):1007-13. doi: 10.1292/jvms.57.1007.
The rapid inhalation induction of anesthesia (RII) by mask inhalation of halothane, enflurane, isoflurane and sevoflurane at an equianesthetic concentration (2.5 MAC) was evaluated in 24 beagle dogs. The differences in movements, induction and intubation time between anesthetics were mainly associated with the differences in each blood/gas solubility. The most rapid and smoothest induction was observed by sevoflurane inhalation (209.0 +/- 44.2 sec), followed by isoflurane inhalation (285.8 +/- 34.1 sec). Halothane inhalation took the longest induction time (790.3 +/- 75.7 sec). Movements during RII were minimal in sevoflurane group comparing to the other groups. Heart rate, cardiac output and rate pressure product significantly increased after the beginning of inhalation in all the dogs except for those of halothane group. These changes exceeded the physiological level just after the beginning of inhalation, however, rapidly reversed to the maintenance level (1.5 MAC) approximately 10 min after intubation. Consequently, sevoflurane seemed to be the best inhalational anesthetic for RII in dogs without significant problems in respiratory and/or cardiac functions. Isoflurane also induced rapid induction with some degree of the movements.
在24只比格犬中评估了通过面罩吸入氟烷、恩氟烷、异氟烷和七氟烷在等效麻醉浓度（2.5 MAC）下进行快速吸入诱导麻醉（RII）的情况。麻醉剂之间在运动、诱导和插管时间上的差异主要与各自的血/气溶解度差异有关。七氟烷吸入诱导最为迅速且平稳（209.0 +/- 44.2秒），其次是异氟烷吸入（285.8 +/- 34.1秒）。氟烷吸入诱导时间最长（790.3 +/- 75.7秒）。与其他组相比，七氟烷组在RII期间的运动最少。除氟烷组外，所有犬只在吸入开始后心率、心输出量和率压积均显著增加。这些变化在吸入开始后刚超过生理水平，但在插管后约10分钟迅速恢复到维持水平（1.5 MAC）。因此，对于呼吸和/或心脏功能无明显问题的犬只，七氟烷似乎是RII的最佳吸入麻醉剂。异氟烷也能诱导快速诱导，但会有一定程度的运动。
