Cooper R G, Stokes M J, Edwards R H
Department of Medicine, University of Liverpool, UK.
J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1134-41. doi: 10.1136/jnnp.51.9.1134.
Contractile properties of adductor pollicis muscle were examined over a range of stimulation frequencies in patients with myotonic dystrophy and normal subjects. In patients, fresh muscle demonstrated impaired relaxation, weakness at all frequencies and selective loss of force and excitation at high frequencies. During stimulated "fatiguing" activity, patients showed improvements in force and relaxation which appeared to result from normalisation of membrane excitation. Normal twitch potentiation also occurred during activity suggesting intact excitation-contraction coupling. These electrophysiological findings help to characterise and explain the "warm up" effect described by patients.
在肌强直性营养不良患者和正常受试者中，在一系列刺激频率下检查了拇收肌的收缩特性。在患者中，新鲜肌肉表现出松弛受损、在所有频率下均无力，以及在高频时选择性地丧失力量和兴奋性。在受刺激的“疲劳”活动期间，患者的力量和松弛有所改善，这似乎是由于膜兴奋性的正常化所致。活动期间也出现了正常的抽搐增强，表明兴奋-收缩偶联完整。这些电生理结果有助于描述和解释患者所描述的“热身”效应。
