Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Mediators Inflamm. 2020 Mar 12;2020:3053520. doi: 10.1155/2020/3053520. eCollection 2020.
One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable gene regulator. This new perspective on mRNA has led to rising interest in it and its presence in research into new therapeutic schemes. This paper, therefore, focuses on microRNAs (miRNAs), which are small noncoding RNAs that regulate posttranscriptional gene expression and play a vital role in the physiology and normative development of cardiovascular systems. This means they play an equally vital role in the development and progression of cardiovascular diseases. In recent years, multiple studies have pinpointed particular miRNA expression profiles as being associated with varying histological features of AF. These studies have been carried out in both animal models and AF patients. The emergence of miRNAs as biomarkers and their therapeutic potential in AF patients will be discussed in the body of this paper.
最常见的一种室上性心律失常是心房颤动（房颤）。信使 RNA（mRNA）的结构和功能知识最近有所增加。它不再被视为 DNA 和蛋白质之间的唯一中间分子，而是被视为一种动态和可修饰的基因调节剂。这种对 mRNA 的新视角引起了人们对其的浓厚兴趣，并将其应用于新的治疗方案的研究中。因此，本文重点介绍 microRNAs（miRNAs），它们是调节转录后基因表达的小非编码 RNA，在心血管系统的生理学和正常发育中发挥着重要作用。这意味着它们在心血管疾病的发展和进展中同样起着至关重要的作用。近年来，多项研究指出，特定的 miRNA 表达谱与房颤的不同组织学特征有关。这些研究在动物模型和房颤患者中都进行过。本文将讨论 miRNA 作为生物标志物的出现及其在房颤患者中的治疗潜力。
