Lin Li, Wu Jianhui, Yuan Yiran, Sun Xianghong, Zhang Liang
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Front Psychiatry. 2020 Feb 28;11:142. doi: 10.3389/fpsyt.2020.00142. eCollection 2020.
The hypothalamic-pituitary-adrenocortical (HPA) function is crucial for adaptation to stress and recovery of homeostasis. Physiological alteration in the HPA axis has been shown to play a pivotal role in the generation of stress-related disorders. A growing number of studies have begun to identify which variables are possible to predict individual HPA response and associated stress vulnerability. The current study investigated the relationship between working memory and the subsequent magnitude of HPA response to psychosocial stress in a non-clinical population. Working memory was assessed utilizing an n-back task (2/3-back) in thirty-nine healthy young men, whose electroencephalograms were recorded. The HPA response was measured using the percentage increase in cortisol to an acute psychosocial stress protocol called the Trier Social Stress Test (TSST). Our results show that longer reaction time and smaller amplitude of P2 predict a relatively lower HPA response to stress. Our study provides new insights into how neurocognitive factors can be used to predict HPA response to acute stress.
下丘脑-垂体-肾上腺皮质（HPA）功能对于适应压力和恢复内稳态至关重要。HPA轴的生理改变已被证明在与压力相关的疾病发生中起关键作用。越来越多的研究开始确定哪些变量有可能预测个体的HPA反应及相关的压力易感性。本研究调查了非临床人群中工作记忆与随后HPA对心理社会压力反应强度之间的关系。在39名健康年轻男性中使用n-back任务（2/3-back）评估工作记忆，并记录其脑电图。使用皮质醇对一种名为特里尔社会压力测试（TSST）的急性心理社会压力方案的增加百分比来测量HPA反应。我们的结果表明，更长的反应时间和更小的P2波幅预示着对压力的HPA反应相对较低。我们的研究为神经认知因素如何用于预测HPA对急性压力的反应提供了新的见解。
