Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2020 Mar 18;11:140. doi: 10.3389/fendo.2020.00140. eCollection 2020.
Pheochromocytoma crisis is a rare and possibly fatal emergency. Hypersecreted catecholamines may result in myocardial injury via its direct toxic effect on cardiomyocytes or mediating vasoconstriction which will reduce coronary blood flow in this special setting. Interestingly, several case studies have reported the occurrence of ST-segment elevation myocardial infarction in patients with pheochromocytoma crisis. However, no one found the angiographic evidence of occlusive thrombus in the infarct-related coronary artery. Additionally, pheochromocytoma can induce hypercoagulability and promote thrombosis, but spontaneous coronary thrombosis has never been reported in this condition. Here, we report an unusual case of pheochromocytoma crisis presenting with STEMI due to spontaneous coronary thrombosis.
嗜铬细胞瘤危象是一种罕见且可能致命的紧急情况。过量分泌的儿茶酚胺可能通过直接对心肌细胞的毒性作用或介导血管收缩导致心肌损伤，从而减少这种特殊情况下的冠状动脉血流。有趣的是，几项病例研究报告了嗜铬细胞瘤危象患者发生 ST 段抬高型心肌梗死。然而，没有人在梗死相关冠状动脉中发现闭塞性血栓的血管造影证据。此外，嗜铬细胞瘤可引起血液高凝状态并促进血栓形成，但在这种情况下从未报道过自发性冠状动脉血栓形成。在这里，我们报告了一例不常见的嗜铬细胞瘤危象病例，由于自发性冠状动脉血栓形成导致 STEMI。
