Osali Ali
Department of General Courses, University of Bonab, Bonab, Iran.
Diabetol Metab Syndr. 2020 Mar 30;12:26. doi: 10.1186/s13098-020-00532-4. eCollection 2020.
Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level.
The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60-65 year females with metabolic syndrome (MS).
Forty-four women with metabolic syndrome (Mets) voluntarily took part in the present study. Participants were randomly divided into 4 groups of MetS exercise + Nano-Curcumin (MENC), MetS exercise (ME), MetS Nano-Curcumin (MNC), MetS control (MC). During the first week, MENC and ME groups participated in three sets of 10-min aerobic exercise training (AT) with a treadmill with 5-min rest parts between the sets. One minute was added to the duration of exercise sets weekly. Blood samples were collected before and after 6 weeks. IL-6, IL-10 and BDNF levels were measured by ELISA method. To analyze the data, Paired-samples t-test with the significance level of (P ≤ 0.05).
IL-10 and BDNF concentrations significantly increased after a 6-week intervention (P ≤ 0.05). Also, IL-6 serum levels significantly decreased (P ≤ 0.05). Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome. In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome.
Findings show that both of the regular exercise and consumption of NanoCurcumin for 6 weeks reduce inflammation. Combination of these two leads to even more reduction of inflammation. The regular exercise led to a decrease at the fat percentage, which deceased IL-6 level and increased IL-10 level. So, this change led to increasing BDNF's levels. IRCT2017082335857N1 Registered 2017-11-16, https://en.irct.ir/trial/26971.
衰老、炎症、氧化应激和代谢综合征是影响脑源性神经营养因子（BDNF）水平的主要重要因素。
本研究旨在探讨为期6周的中等强度有氧运动和服用纳米姜黄素对60 - 65岁患有代谢综合征（MS）女性的白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和BDNF的影响。
44名患有代谢综合征（Mets）的女性自愿参与本研究。参与者被随机分为4组：代谢综合征运动 + 纳米姜黄素组（MENC）、代谢综合征运动组（ME）、代谢综合征纳米姜黄素组（MNC）、代谢综合征对照组（MC）。在第一周，MENC组和ME组使用跑步机进行三组10分钟的有氧运动训练（AT），每组之间休息5分钟。每周运动组的持续时间增加1分钟。在6周前后采集血样。采用酶联免疫吸附测定（ELISA）法测量IL-6、IL-10和BDNF水平。为分析数据，采用显著性水平为（P≤0.05）的配对样本t检验。
经过6周干预后，IL-10和BDNF浓度显著升高（P≤0.05）。此外，IL-6血清水平显著降低（P≤0.05）。此外，本研究结果表明，补充纳米姜黄素可显著降低代谢综合征患者血清中丙二醛（MDA）和高敏C反应蛋白（hs-CRP）的浓度。此外，本研究结果表明，补充纳米姜黄素可显著提高代谢综合征患者血清中BDNF、IL-10和总抗氧化能力（TAC）的浓度。
研究结果表明，规律运动和服用纳米姜黄素6周均可减轻炎症。两者结合可进一步减轻炎症。规律运动导致体脂百分比降低，进而降低IL-6水平并提高IL-10水平。因此，这种变化导致BDNF水平升高。IRCT201708233 . 5857N1于2017年11月16日注册，https://en.irct.ir/trial/26971 。
