沉默调节蛋白4（SIRT4），一种在癌症中具有致癌和抑癌活性的治疗靶点。
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer.
作者信息
Huang Guoyu, Zhu Guanbao
机构信息
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China.
出版信息
Onco Targets Ther. 2018 Jun 11;11:3395-3400. doi: 10.2147/OTT.S157724. eCollection 2018.
Abstract
Several members of the sirtuin (SIRT) family, a highly conserved family of NAD-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tumors was investigated. Subsequently, we evaluated the role of SIRT4 with oncogenic or tumor-suppressive activity in cancer, which may provide insight in identifying the underlying mechanism of action of SIRT4 in cancer. Finally, we explored the potential of SIRT4 as a therapeutic target in cancer therapy.
摘要
沉默调节蛋白（SIRT）家族是一类高度保守的依赖烟酰胺腺嘌呤二核苷酸（NAD）的酶，该家族的几个成员已被证明在促进和/或抑制肿瘤发生中起关键作用。在本研究中，我们综述了该领域关于SIRT4与癌症的最新进展，并研究了SIRT4与肿瘤之间的关系。随后，我们评估了具有致癌或抑癌活性的SIRT4在癌症中的作用，这可能有助于深入了解SIRT4在癌症中的潜在作用机制。最后，我们探讨了SIRT4作为癌症治疗中治疗靶点的潜力。
相似文献
1
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer.沉默调节蛋白4（SIRT4），一种在癌症中具有致癌和抑癌活性的治疗靶点。
Onco Targets Ther. 2018 Jun 11;11:3395-3400. doi: 10.2147/OTT.S157724. eCollection 2018.
2
SIRT4 is upregulated in breast cancer and promotes the proliferation, migration and invasion of breast cancer cells.SIRT4在乳腺癌中上调，并促进乳腺癌细胞的增殖、迁移和侵袭。
Int J Clin Exp Pathol. 2017 Dec 1;10(12):11849-11856. eCollection 2017.
3
SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism.SIRT4 通过诱导细胞凋亡和抑制谷氨酰胺代谢来发挥抑癌作用，从而抑制前列腺癌的发生。
Sci Rep. 2022 Jul 16;12(1):12208. doi: 10.1038/s41598-022-16610-8.
4
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.结直肠癌中 Sirtuin-4 表达的临床和治疗意义。
Oncol Rep. 2016 May;35(5):2801-10. doi: 10.3892/or.2016.4685. Epub 2016 Mar 17.
5
Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells.敲除SIRT4可降低结肠癌细胞对5-氟尿嘧啶的化疗敏感性。
Oncol Lett. 2018 Aug;16(2):1675-1681. doi: 10.3892/ol.2018.8850. Epub 2018 May 31.
6
Decreased SIRT4 protein levels in endometrioid adenocarcinoma tissues are associated with advanced AJCC stage.子宫内膜样腺癌组织中SIRT4蛋白水平降低与美国癌症联合委员会（AJCC）晚期分期相关。
Cancer Biomark. 2017 Jul 4;19(4):419-424. doi: 10.3233/CBM-160419.
7
Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma.沉默调节蛋白4（SIRT4）在胃腺癌中表达下调，并与一些临床病理特征相关。
Biomed Pharmacother. 2015 May;72:135-9. doi: 10.1016/j.biopha.2015.04.013. Epub 2015 Apr 27.
8
Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest.SIRT4的过表达通过细胞周期阻滞抑制胃癌细胞的增殖。
Oncol Lett. 2019 Feb;17(2):2171-2176. doi: 10.3892/ol.2018.9877. Epub 2018 Dec 28.
9
Tumour-suppressive function of SIRT4 in human colorectal cancer.SIRT4在人类结直肠癌中的肿瘤抑制功能
Br J Cancer. 2015 Jul 28;113(3):492-9. doi: 10.1038/bjc.2015.226. Epub 2015 Jun 18.
10
Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer.哺乳动物SIRT4在细胞代谢中的功能及在人类癌症中的研究进展
Oncol Lett. 2020 Oct;20(4):11. doi: 10.3892/ol.2020.11872. Epub 2020 Jul 15.
引用本文的文献
1
Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes.乳腺癌中生物胺相关基因和微小RNA的亚型特异性失调：确定DRD2、HRH2和HRH4为三阴性乳腺癌和HER2 +亚型的潜在治疗靶点。
Breast Cancer Res Treat. 2025 May 27. doi: 10.1007/s10549-025-07732-4.
2
SIRT4 Controls Acetyl-CoA Synthesis to Promote Stemness and Invasiveness of Hepatocellular Carcinoma through Deacetylating MCCC2.SIRT4通过使MCCC2去乙酰化来控制乙酰辅酶A的合成，从而促进肝细胞癌的干性和侵袭性。
Int J Biol Sci. 2025 Apr 21;21(7):2973-2990. doi: 10.7150/ijbs.99004. eCollection 2025.
3
The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia-A Promising Road Ahead.沉默调节蛋白家族组蛋白去乙酰化酶在急性髓系白血病中的作用——前路光明。
Cancers (Basel). 2025 Mar 17;17(6):1009. doi: 10.3390/cancers17061009.
4
Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications.沉默调节蛋白作为胰腺癌的关键调节因子：对信号传导机制及治疗意义的见解
Cancers (Basel). 2024 Dec 6;16(23):4095. doi: 10.3390/cancers16234095.
5
The diagnostic value and associated molecular mechanism study for fibroblast-related mitochondrial genes on keloid.瘢痕疙瘩中成纤维细胞相关线粒体基因的诊断价值及相关分子机制研究。
Skin Res Technol. 2024 Sep;30(9):e70024. doi: 10.1111/srt.70024.
6
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis.Sirt1：一种在骨骼代谢和骨质疏松症中具有潜在作用的日益引人关注的分子。
Biomolecules. 2024 Aug 8;14(8):970. doi: 10.3390/biom14080970.
7
Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets.靶向头颈部鳞状细胞癌中的组蛋白去乙酰化酶：分子机制和治疗靶点。
J Transl Med. 2024 May 3;22(1):418. doi: 10.1186/s12967-024-05169-9.
8
Natural Phytochemicals as SIRT Activators-Focus on Potential Biochemical Mechanisms.天然植物化学物作为 SIRT 激活剂——关注潜在的生化机制。
Nutrients. 2023 Aug 14;15(16):3578. doi: 10.3390/nu15163578.
9
SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy.SIRT4是膀胱癌的一个独立预后因素，通过抑制自噬来抑制膀胱癌生长。
Cell Div. 2023 Jun 10;18(1):9. doi: 10.1186/s13008-023-00091-w.
10
The Role of NAD+, SIRTs Interactions in Stimulating and Counteracting Carcinogenesis.NAD+、SIRTs 相互作用在刺激和拮抗致癌作用中的角色。
Int J Mol Sci. 2023 Apr 27;24(9):7925. doi: 10.3390/ijms24097925.
本文引用的文献
1
Decreased SIRT4 protein levels in endometrioid adenocarcinoma tissues are associated with advanced AJCC stage.子宫内膜样腺癌组织中SIRT4蛋白水平降低与美国癌症联合委员会（AJCC）晚期分期相关。
Cancer Biomark. 2017 Jul 4;19(4):419-424. doi: 10.3233/CBM-160419.
2
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.SIRT4是一种控制亮氨酸代谢和胰岛素分泌的赖氨酸脱酰基酶。
Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003.
3
SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway.SIRT4通过由ERK-Drp1途径介导的线粒体动力学抑制非小细胞肺癌的恶性进展。
Oncogene. 2017 May 11;36(19):2724-2736. doi: 10.1038/onc.2016.425. Epub 2016 Dec 12.
4
Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer.沉默调节蛋白4表达降低与浸润性乳腺癌患者的不良预后相关。
Oncol Lett. 2016 Oct;12(4):2606-2612. doi: 10.3892/ol.2016.5021. Epub 2016 Aug 16.
5
Sirtuin functions and modulation: from chemistry to the clinic.沉默调节蛋白的功能与调控：从化学到临床
Clin Epigenetics. 2016 May 25;8:61. doi: 10.1186/s13148-016-0224-3. eCollection 2016.
6
Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.癌症中的线粒体去乙酰化酶：新出现的作用和治疗潜力
Cancer Res. 2016 May 1;76(9):2500-6. doi: 10.1158/0008-5472.CAN-15-2733. Epub 2016 Apr 20.
7
Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma.SIRT4表达下调与食管鳞状细胞癌的不良预后相关。
Oncology. 2016;90(6):347-55. doi: 10.1159/000445323. Epub 2016 Apr 16.
8
High-throughput screening of Sirtuin family of genes in breast cancer.乳腺癌中沉默调节蛋白基因家族的高通量筛选
Gene. 2016 Jul 15;586(1):123-8. doi: 10.1016/j.gene.2016.04.023. Epub 2016 Apr 11.
9
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.结直肠癌中 Sirtuin-4 表达的临床和治疗意义。
Oncol Rep. 2016 May;35(5):2801-10. doi: 10.3892/or.2016.4685. Epub 2016 Mar 17.
10
Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.研究烟酰胺腺嘌呤二核苷酸（NAD⁺）依赖性去乙酰化酶活性对还原型烟酰胺腺嘌呤二核苷酸（NADH）的敏感性。
J Biol Chem. 2016 Mar 25;291(13):7128-41. doi: 10.1074/jbc.M115.668699. Epub 2016 Feb 9.
Zotero 插件