Huang Guoyu, Zhu Guanbao
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China.
Onco Targets Ther. 2018 Jun 11;11:3395-3400. doi: 10.2147/OTT.S157724. eCollection 2018.
Several members of the sirtuin (SIRT) family, a highly conserved family of NAD-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tumors was investigated. Subsequently, we evaluated the role of SIRT4 with oncogenic or tumor-suppressive activity in cancer, which may provide insight in identifying the underlying mechanism of action of SIRT4 in cancer. Finally, we explored the potential of SIRT4 as a therapeutic target in cancer therapy.
沉默调节蛋白（SIRT）家族是一类高度保守的依赖烟酰胺腺嘌呤二核苷酸（NAD）的酶，该家族的几个成员已被证明在促进和/或抑制肿瘤发生中起关键作用。在本研究中，我们综述了该领域关于SIRT4与癌症的最新进展，并研究了SIRT4与肿瘤之间的关系。随后，我们评估了具有致癌或抑癌活性的SIRT4在癌症中的作用，这可能有助于深入了解SIRT4在癌症中的潜在作用机制。最后，我们探讨了SIRT4作为癌症治疗中治疗靶点的潜力。
