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急性爱泼斯坦-巴尔病毒相关性心肌炎:免疫功能正常患者中一种罕见但危及生命的疾病。

Acute Epstein-Barr related myocarditis: An unusual but life-threatening disease in an immunocompetent patient.

作者信息

Watanabe Mikiko, Panetta Gaetano Luca, Piccirillo Francesco, Spoto Silvia, Myers Jordan, Serino Francesco Maria, Costantino Sebastiano, Di Sciascio Germano

机构信息

«Doctors in Italy» Association, Rome, Italy.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

出版信息

J Cardiol Cases. 2019 Dec 26;21(4):137-140. doi: 10.1016/j.jccase.2019.12.001. eCollection 2020 Apr.

Abstract

Myocarditis is an uncommon but potentially life-threatening disease. Clinical manifestations could range from subclinical disease to sudden death, due to fulminant heart failure and/or malignant ventricular arrhythmias. The most common cause of myocarditis is viral infection, including Epstein-Barr virus (EBV). Nevertheless, EBV rarely presents with cardiac involvement in immunocompetent hosts. We report a case of acute EBV-related myocarditis in a young female, complicated with malignant ventricular arrhythmias and cardiac arrest. After 20 days of hospitalization and treatment, the patient was fit for discharge on pharmacological therapy (tapering steroids, beta-blockers, amiodarone, angiotensin-converting enzyme inhibitors, and diuretics). Clinical course is described, cardiac magnetic resonance images are shown. This case underlines how myocarditis is a disease that should not be underestimated: it could present with life-threatening complications such as malignant arrhythmias and/or severe systolic dysfunction. < Although Epstein-Barr virus rarely presents with cardiac involvement in immunocompetent hosts, the risk should not be underestimated, as it could present with life-threatening complications.>.

摘要

心肌炎是一种罕见但可能危及生命的疾病。其临床表现范围广泛,从亚临床疾病到因暴发性心力衰竭和/或恶性室性心律失常导致的猝死。心肌炎最常见的病因是病毒感染,包括Epstein-Barr病毒(EBV)。然而,在免疫功能正常的宿主中,EBV很少出现心脏受累情况。我们报告一例年轻女性急性EBV相关性心肌炎病例,该病例并发恶性室性心律失常和心脏骤停。经过20天的住院治疗,患者在接受药物治疗(逐渐减量的类固醇、β受体阻滞剂、胺碘酮、血管紧张素转换酶抑制剂和利尿剂)后适合出院。文中描述了临床病程,并展示了心脏磁共振图像。该病例强调了心肌炎是一种不应被低估的疾病:它可能会出现危及生命的并发症,如恶性心律失常和/或严重的收缩功能障碍。<尽管在免疫功能正常的宿主中,Epstein-Barr病毒很少出现心脏受累情况,但这种风险不应被低估,因为它可能会出现危及生命的并发症。>

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/726a/7125385/4be7827a0b42/gr1.jpg

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